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1Genomic instability

'Genomic instability' 에 대한 통합검색결과 87건입니다.

한빛사87건

최신순
관련도순

- 정효빈(연세대학교)
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype
- Nat. Genet. 25 November 2024 | https://doi.org/10.1038/s41588-024-01999-x
- 2024.11
Concordance of ctDNA and tissue genomic profiling in advanced biliary tract cancer
- J. Hepatol. Available online 21 October 2024 | https://doi.org/10.1016/j.jhep.2024.10.020
- 2024.10
- 의약학
Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells
- Nucleic Acids Res. Oct 01 2024, gkae842 | https://doi.org/10.1093/nar/gkae842
- 2024.10
- 생명과학
- 허준영(Rutgers, The State University of New Jersey)
RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication
- J. Clin. Invest. Mar 26 2024, 134 (10) e167419 | https://doi.org/10.1172/JCI167419
- 2024.03
- 생명과학
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation
- Leukemia Mar 21 2024, | https://doi.org/10.1038/s41375-024-02228-4
- 2024.03
- 의약학
윤정현

아주대학교 의과대학

전체 인간의 유전체 중 약 75%가 transcription 될 수 있고 그 중 약 2% 이하가 protein coding gene입니다. Transcription이 활발하게 일어나는 유전체는 DNA break에 취약하다고 알려져 있습니다. 이러한 DNA break을 올바르게 복구하지 못하게 되면, 유전체 염기서열의 돌연변이 및 손실이 발생되고 각종 암과 같은 질병이 될 가능성이 높아집니다.
- Nucleic Acids Res.
- 2024.03.05
- 이광석(DKFZ, and NCT Heidelberg)
Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions
- Nat. Commun. Jan 02 2024, 15 (1) | https://doi.org/10.1038/s41467-023-44360-2
- 2024.01
- 양태환(Georgia Institute of Technology)
Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial geno
- Nucleic Acids Res. Dec 20 2023, gkad1204 | https://doi.org/10.1093/nar/gkad1204
- 2023.12
- 생명과학
Heeyoun Bunch

경북대학교

We identified that ERK2 is important for the transcriptional activation in human immediate early genes (IEGs) such as EGR1 and FOS. Unlike ERK2, ERK1 suppresses EGR1 gene activation. ERK2 requires ELK1 binding to stimulate transcriptional activation at EGR1. Importantly, we found that ERK1 and ERK2 phosphorylate and regulate topoisomerase II (TOP2) in different manners.
- Nat. Commun.
- 2023.12.19
- 주윤기(Yale University)
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei
- Mol. Cell Oct 19 2023, 83 (20) S1097-2765(23)00698-6 | https://doi.org/10.1016/j.molcel.2023.09.003
- 2023.10
- 생명과학
- 송홍선(DGIST)
- 기영훈(DGIST)
OTUD5 limits replication fork instability by organizing chromatin remodelers
- Nucleic Acids Res. Sep 15 2023, gkad732 | https://doi.org/10.1093/nar/gkad732
- 2023.09
- 생명과학
- 김보라(The University of Texas Health Science Center at Houston)
Systematic investigation of the homology sequences around the human fusion gene breakpoints in pan-cancer ? bioinformatics study for a potential link
- Brief. Bioinform. 2023 Aug 26;bbad314 | https://doi.org/10.1093/bib/bbad314
- 2023.08
- 생명과학
- 류재욱(경희대학교)
  Interview
- 김자은(경희대학교)
Urban dust particles disrupt mitotic progression by dysregulating Aurora kinase B-related functions
- J. Hazard. Mater. 2023 Aug 6;459:132238 | https://doi.org/10.1016/j.jhazmat.2023.132238
- 2023.08
- 의약학
PAIP 2020: Microsatellite instability prediction in colorectal cancer
- Med. Image Anal. 2023 Jul 8;89:102886 | https://doi.org/10.1016/j.media.2023.102886
- 2023.07
- 의약학
- 하택집(Johns Hopkins University)
Mapping cellular responses to DNA double-strand breaks using CRISPR technologies
- Trends Genet. 2023 Mar 25;S0168-9525(23)00055-0 | https://doi.org/10.1016/j.tig.2023.02.015
- 2023.03
- 박정수(Harvard Medical School)
Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers
- Clin. Cancer Res. Nov 01 2022, 28 (21) | https://doi.org/10.1158/1078-0432.CCR-22-0749
- 2022.11
- 의약학
- 홍주영(University of Texas Health Science Center at San Antonio)
- 이지훈(The University of Texas Health Science Center at San Antonio)
Biological roles of the RNA m6A modification and its implications in cancer
- Exp. Mol. Med. 2022 Nov;54(11):1822-1832 | https://doi.org/10.1038/s12276-022-00897-8
- 2022.11
- 생명과학
- 박웅기(Memorial Sloan Kettering Cancer Center)
Clinico-genomic characterization of ATM and HRD in Pancreas Cancer: Application for Practice
- Clin. Cancer Res. SEPTEMBER 28 2022 | https://doi.org/10.1158/1078-0432.CCR-22-1483
- 2022.09
- 생명과학
- 이은희(Jackson Laboratory for Genomic Medicine)
Extrachromosomal DNA amplifications in cancer
- Nat. Rev. Genet. Published 11 August 2022 | https://doi.org/10.1038/s41576-022-00521-5
- 2022.08
- 의약학
Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes
- Hepatology First published: 29 March 2022 | https://doi.org/10.1002/hep.32490
- 2022.03
- 의약학