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통합검색

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'Computational Biology' 에 대한 통합검색결과 322건입니다.

한빛사322건

최신순
관련도순

- 허우녕(Duke University School of Medicine, 현 The Rockefeller University & Memorial Sloan Kettering Cancer Center)
  Interview
Topological interactions drive the first fate decision in the Drosophila embryo
- Nat. Phys. 25 February 2025 | https://doi.org/10.1038/s41567-025-02796-x
- 2025.02
- 생명과학
Zinah Hilal Khaleel

성균관대학교

1. Can you please briefly summarize the paper? This article details the design of a photoswitchable organic–peptide hybrids that self-associate into Ca 2+ -binding dimers when exposed to specific light wavelengths. This research highlights the potential of photoswitchable compounds to regulate complex equilibria, enabling the design of photoactive systems. These findings could lead to applications in various fields, demonstrating the ability to control protein behavior with light and targeted metal in this case calcium. 2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them? One of the main challenges I faced during my laboratory work was maintaining motivation, especially when progress felt slow or results were elusive. To overcome this, I learned to pause and reflect on how far I’d come, which helped me regain perspective and stay focused. Another difficulty was dealing with unexpected or unfavorable results. When experiments didn’t go as planned, I focused on being constructive evaluating whether the data could still be useful or identifying lessons to improve future work. There were also moments when I realized my research direction needed adjustment. Instead of seeing this as a setback, I embraced flexibility, adapted my approach, and found new ways to move forward. Finally, time management was a constant challenge. I worked on setting realistic goals, avoiding overloading my schedule, and accepting that some time pressure is inherent to the process. These strategies helped me stay productive and resilient throughout my PhD journey. 3. Please introduce your laboratory, university or organization to bio-researchers in Korea. I worked at the YH Protein Design Laboratory, a cutting-edge research group focused on protein engineering and design. The lab specializes in developing innovative approaches to understand, predict, and manipulate protein structures and functions, with applications rangin
- Proc. Natl. Acad. Sci. USA
- 2025.02.14
Control of Cellular Differentiation Trajectories for Cancer Reversion
- Adv. Sci. Dec 11 2024, | https://doi.org/10.1002/advs.202402132
- 2024.12
- 생명과학
Synthetic translational coupling element for multiplexed signal processing and cellular control
- Nucleic Acids Res. 11 November 2024 | https://doi.org/10.1093/nar/gkae980
- 2024.11
- 생명과학
Nanoscale single-vesicle analysis: High-throughput approaches through AI-enhanced super-resolution image analysis
- Biosens. Bioelectron. Nov 01 2024, 263 S0956-5663(24)00635-3 | https://doi.org/10.1016/j.bios.2024.116629
- 2024.11
- 바이오·의료융합
Seq-Scope: repurposing Illumina sequencing flow cells for high-resolution spatial transcriptomics
- Nat. Protoc. Oct 31 2024, | https://doi.org/10.1038/s41596-024-01065-0
- 2024.10
- 생명과학
- 윤찬식(KAIST, 현 Northwestern University)
- 이균민(KAIST)
SiMPl-GS: Advancing Cell Line Development via Synthetic Selection Marker for Next-Generation Biopharmaceutical Production
- Adv. Sci. Aug 06 2024, | https://doi.org/10.1002/advs.202405593
- 2024.08
- 생명과학
- 김승현(Delft University of Technology, 이화여자대학교)
- 주철민(Delft University of Technology, 이화여자대학교)
iMAX FRET (Information Maximized FRET) for Multipoint Single-Molecule Structural Analysis
- Nano Lett. Jul 08 2024, | https://doi.org/10.1021/acs.nanolett.4c00447
- 2024.07
- 생명과학
- 신승원(University of California Berkeley)
FIND-seq: high-throughput nucleic acid cytometry for rare single-cell transcriptomics
- Nat. Protoc. Jul 22 2024, | https://doi.org/10.1038/s41596-024-01021-y
- 2024.07
- 임원필(Lehigh University, Bethlehem)
CHARMM-GUI Multicomponent Assembler for modeling and simulation of complex multicomponent systems
- Nat. Commun. 27 June 2024 | https://doi.org/10.1038/s41467-024-49700-4
- 2024.06
김장근

Weill Cornell Medicine

인터뷰를 통해 2024년 Nature Portfolio를 통해 출판된 Space Omics and Medical Atlas (SOMA) across orbits 논문 패키지를 소개할 수 있게 되어 기쁩니다. SOMA across orbits는 25개 이상 국가, 100개 이상 연구기관이 협력하여 우주비행에 의한 세포, 조직, 개체, 및 시스템적인 변화와 이의 대응방안에 대한 44개의 논문으로 구성되어 있습니다.
- Nat. Microbiol.
- 2024.06.20
- 김재범(서울대학교 기계학습 및 생물정보학 연구실)
  Interview
- Martin Steinegger(서울대학교)
Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA
- Nat. Methods Published: 20 May 2024 | https://doi.org/10.1038/s41592-024-02273-y
- 2024.05
- 생명과학
명유찬

The University of Queensland

최근 신약 개발 동향을 살펴보면, 대형 제약회사의 전임상 연구 중 Pharmacokinetics (PK) 와 독성 평가단계에서 가장 많은 약물 후보물질들이 리스트에서 제외된다고 합니다. 결국, 후보물질 스크리닝 단계에서 물질의 효능만을 살펴보는 것이 아니라 PK 및 독성 예측값을 사용하여 후보 물질의 개발성 (developability)을 전반적으로 평가하는 것이 신약 개발 성공률을 높이는 방법이 될 것입니다.
- Nucleic Acids Res.
- 2024.05.07
이효형

서울대학교, Icahn School of Medicine at Mount Sinai

Psoriasis is a chronic, T-cell-mediated inflammatory skin disease with a Th17-skewed immune phenotype. Regulatory T cells (Tregs) play a key role in suppressing the inflammatory immune response and inducing immune homeostasis and self-tolerance. While the role of Tregs in the pathogenesis of psoriasis has been proposed, the exact mechanisms of action and the molecular characterization of skin-homing psoriatic Tregs has not yet been well explored.
- EBioMedicine
- 2024.02.16
- 라제쉬쿠마르파닥(중앙대학교)
- 김준모(중앙대학교)
Veterinary systems biology for bridging the phenotype-genotype gap via computational modeling for disease epidemiology and animal welfare
- Brief. Bioinform. Jan 22 2024, 25 (2) bbae025 | https://doi.org/10.1093/bib/bbae025
- 2024.01
- 생명과학
- 문태석(Washington University in St. Louis)
Advances in ligand-specific biosensing for structurally similar molecules
- Cell Syst. Dec 20 2023, 14 (12) S2405-4712(23)00301-0 | https://doi.org/10.1016/j.cels.2023.10.009
- 2023.12
- 생명과학
Understanding the Mechanobiology of Phytoacoustics Through Molecular Lens: Mechanisms and Future Perspectives
- J. Adv. Res. Dec 13 2023, S2090-1232(23)00398-3 | https://doi.org/10.1016/j.jare.2023.12.011
- 2023.12
- 생명과학
이영호

서울대학교

유전체 DNA는 각 개체가 가진 고유 정보일 뿐만 아니라 생명체의 모든 형질과 진화의 기원을 담고 있는 유전자원입니다. 각 종을 대표하는 참조유전체(Reference genome)는 한 생명체의 DNA 염기서열을 잘게 잘라 해독하고 조립하여 만들어집니다. 이렇게 완성된 참조유전체는 다른 종과의 차이를 규명하는 비교유전체 분석이나 해당 종의 다양한 조직이나 발달과정 등에서 차이를 규명하는 전사체, 후성유전체 등 다양한 차원의 후속 연구를 수행하는 데 기반자료로 활용됩니다.
- Sci. Data
- 2023.12.18
Nhat Truong Pham

성균관대학교

Hello, I’m Nhat Truong Pham, a first-year Ph.D. student working under Prof. Balachandran Manavalan at the Computational Biology and Bioinformatics Laboratory (CBBL-SKKU: https://balalab-skku.org/), Department of Integrative Biotechnology at Sungkyunkwan University. First of all, I’m grateful to the Biological Research Information Center (BRIC) for providing me with this exceptional opportunity
- Brief. Bioinform.
- 2023.12.15
문창인

Baylor College of Medicine

안녕하세요, 저는 미국 베일러 의과대학(Baylor College of Medicine)에서 Quantitative and Computational Science 분야의 박사과정 4학년 차인 문창인입니다. 먼저 이 자리를 통해 저의 연구와 저희 연구실을 소개할 수 있는 기회를 제공해주신 BRIC 관계자 여러분들과 이 인터뷰를 읽고 계신 모든 분들께 진심으로 감사의 인사를 전하고 싶습니다.
- Nucleic Acids Res.
- 2023.12.12