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1CNS development

'CNS development' 에 대한 통합검색결과 63건입니다.

한빛사63건

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- Ngoc Man Phan(성균관대학교)
- 김재윤(성균관대학교)
Mesoporous polydopamine nanoparticle-based tolerogenic vaccine induces antigen-specific immune tolerance to prevent and treat autoimmune multiple scle
- Biomaterials Dec 06 2024, 316 S0142-9612(24)00533-7 | https://doi.org/10.1016/j.biomaterials.2024.122997
- 2024.12
- 바이오·의료융합
- 강혜진(연세대학교)
Structure-guided design of a peripherally restricted chemogenetic system
- Cell December 3, 2024 | https://doi.org/10.1016/j.cell.2024.11.001
- 2024.12
- 생명과학
- 최혜규(Rutgers, The State University of New Jersey)
- 이기범(Rutgers, The State University of New Jersey)
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
- Nano Converg. May 13 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00426-5
- 2024.05
- 바이오·의료융합
- Khoa Nguyen Tran(동국대학교)
- 양인준(동국대학교)
Intranasal delivery of herbal medicine for disease treatment: A systematic review
- Phytomedicine Feb 28 2024, 127 S0944-7113(24)00148-X | https://doi.org/10.1016/j.phymed.2024.155484
- 2024.02
- 김형우(서울대학교, 현 Harvard Medical School )
- 오석배(서울대학교)
The therapeutic potential of natural killer cells in neuropathic pain
- Trends Neurosci. Available online 27 June 2023 | https://doi.org/10.1016/j.tins.2023.05.008
- 2023.06
- 의약학
- Sarmistha Mitra(동국대학교)
- 문일수(동국대학교 의과대학)
Brain modulation by the gut microbiota: From disease to therapy
- J. Adv. Res. 2022 Dec 7;S2090-1232(22)00267-3 | https://doi.org/10.1016/j.jare.2022.12.001
- 2022.12
- 박인현(Yale School of Medicine)
Advanced in vitro models: Microglia in action
- Neuron 2022 Nov 2;110(21):3444-3457 | https://doi.org/10.1016/j.neuron.2022.10.004
- 2022.11
- 생명과학
- 신준하(University of Wisconsin-Madison)
Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns
- Sci. Adv. 30 Sep 2022 Vol 8, Issue 39 | https://doi.org/10.1126/sciadv.abn7430
- 2022.09
Anderson Tan

서울시립대학교

1. Can you please briefly summarize the paper? Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, is a well established central regulator of the autophagy/lysosomal-to-nucleus signaling pathway. Our group under the guidance of Prof. Jho Eek Hoon had recently published 2 significant papers about the novel roles of TFEB in CDDpress journals - Cell Death and Differentiation and Cell Death & Disease . In particular, the paper published in Cell Death & Disease , where I am the first author, was selected as ‘’CDDpress: Our Monthly Top Picks’’. Not long ago, we had also successfully published an exhaustive and comprehensive review of TFEB in Cell Death and Differentiation (IF; 15.8). In my personal humble opinion, our findings on TFEB represents a breakthrough in TFEB field as we challenged the long standing dogma of TFEB as a regulator of autophagy/lysosomal biogenesis. To commemorate the 30th anniversary of TFEB since its first discovery, we have decided to write a comprehensive review paper entitled ‘’Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association with disease’’, which was successfully published in Cell Death & Differentiation . I personally feel that a comprehensive review paper that discusses the future direction of TFEB is essential as it open up new research areas. In our review article, we analyze the past, present, and future perspectives of TFEB throughout the previous 30 years and provide thorough insights. There are six sections to this extensive review paper ranging from TFEB evolution, its massive involvement in signaling pathways and diseases and TFEB role in the centrality and dynamics of lysosomes. We also discussed the recently discovered autophagy-lysosomal-independent role of TFEB and its future prospects as an appealing therapeutic target in modulating health and disease. Our revie
- Cell Death Differ.
- 2022.07.04
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease
- npj Regen. Med. Published 13 January 2022 | https://doi.org/10.1038/s41536-021-00199-z
- 2022.01
- 생명과학
- 최진경(전북대학교 의과대학, NIH)
IL-27?producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases
- Proc. Natl. Acad. Sci. USA November 23, 2021, 118 (47) : e2109548118 | https://doi.org/10.1073/pnas.210954811823;118
- 2021.11
- 의약학
- 이기범(Rutgers, The State University of New Jersey)
Hybrid SMART spheroids to enhance stem cell therapy for CNS injuries
- Sci. Adv. 29 Sep 2021, Vol 7, Issue 40 | DOI: 10.1126/sciadv.abj2281
- 2021.09
- 바이오·의료융합
- 김기철(University of California, San Francisco)
  Interview
Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis
- Brain Published: 29 December 2020 | https://doi.org/10.1093/brain/awaa421
- 2020.12
- 안은희(Emory University School of Medicine)
  Interview
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features
- EMBO J. 22 December 2020, e105537 | https://doi.org/10.15252/embj.2020105537
- 2020.12
- 의약학
- 이현경(Baylor College of Medicine)
The Daam2?VHL?Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation
- Genes Dev. Published in Advance August 13, 2020 | 10.1101/gad.338046.120
- 2020.08
- 의약학
Microphysiological systems for recapitulating physiology and function of blood-brain barrier
- Biomaterials Available online 26 December 2019, Volume 232, 119732 | https://doi.org/10.1016/j.biomaterials.2019.119732
- 2019.12
- 바이오·의료융합
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
- Prog. Neurobiol. Available online 13 December 2017 | https://doi.org/10.1016/j.pneurobio.2017.12.003
- 2017.12
- 의약학
신종현

University of Louisville School of Medicine

1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 사람의 신체 대부분이 근육 (Skeletal Muscle)으로 이루어져 있다. 근육은 신체를 움직이게 돕고, 몸의 위치나 부위를 지지해 주며, 온도를 조절하고, 신체의 다른 장기조직을 지지하고, 음식의 섭취 및 배출을 용이하게 해줄 만큼 우리 몸을 구성하는 데 있어서 중요한 역할을 하고 있다. 근육 세포 (myoblasts) 및 성체 근육 줄기세포 (adult muscle stem cells also called satellite cells)는 myogenesis 과정을 거치며 근섬유 (myofibers)를 형성하고 근육의 성장 (growth)과 발달 (development)을 돕고, 근육이 재생 (regeneration)하는 데 중추 역할을 한다. 근육 세포 또는 성체 근육 줄기세포는 세포의 proliferation, movement, alignment, fusion, and differentiation의 단계를 거치면서 배아 근육 및 재생 근육을 형성하게 된다. 특히, myogenesis 중 근육세포 fusion은 근육 발달 및 재생에 있어서 중요한 단계 중 하나이다. 본 논문은 Toll-like receptors (TLRs) 이나 Interleukin-1의 시그널에 따라 조절되는 myeloid differentiation primary response gene 88 (Myd88) 단백질이 어떻게 myoblast myogenesis에 영향을 끼치고, myoblast fusion에 영향을 끼치는 것이 확실한지 증명하는데 중요한 의의가 있었다. Immunity에 중요한 역할을 하는 Myd88으로 알려져 왔기에 immune cells이 아닌 근육의 세포수준에서 어떠한 영향을 끼치는 지는 거의 알려진바 없었다. Whole body Myd88-KO 마우스 모델에서 regenerative myogenesis을 일으키는 기법을 사용했을시 Myd88이 myogenesis 중 proliferation인지 differentiation 단계인지 알아보는 데에도 많은 시간과 노력이 들어갔다. Primary 근육 성체 줄기 세포를 분리하기도 하고, muscle hind limbs 중 tribialis anterior (TA) 근육의 myofibers를 적출하여 근육 세포가 어느 단계에 깊게 관여하는 지 알아보기도 했다. 한가지씩 myogenesis의 단계들을 여러가지 molecular biology techniques 을 사용하여 체크하고, 관여하지 않은 단계들을 제하면서 fusion에 관여 할 것이라는 추정을 하게 되었다. 특히, myoblast fusion에 관여하는 단백질의 유전자들 (β1-integrin, β1D-integrin adam12, myomaker 등) 이 조절된다는 사실을 확인했을 때, myoblast chimeric 실험에서Myd88 단백질 결여가 myoblas
- Nat. Commun.
- 2017.12.01
- 이선재(KTH-Royal Institute of Technology)
TCSBN: a database of tissue and cancer specific biological networks
- Nucleic Acids Res. Published: 24 October 2017 | https://doi.org/10.1093/nar/gkx994
- 2017.10
- 의약학
- 이선재(KTH-Royal Institute of Technology)
Network analyses identify liver‐specific targets for treating liver diseases
- Mol. Syst. Biol. Published online 21.08.2017, 13: 938 | DOI 10.15252/msb.20177703
- 2017.08
- 의약학