한빛사41건

• • 최규호(부산대학교)

  • 강현구(부산대학교)

  • 김태진(부산대학교)

  • 윤부현(부산대학교)

  Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals

  • Biomater. Res. 2024, 28 0010 | https://doi.org/10.34133/bmr.0010

  • 2024.03
  • 생명과학
• 

  우종찬

  University of Wyoming, 서울대학교

  식물 곰팡이 병에 의한 작물의 피해는 전세계적으로 상상을 초월한 정도로 피해가 막심합니다. 현재, 많은 살균제를 처리 함에도 불구하고, 잿빛곰팡이균에 의한 작물 피해는 년간 10억 달러 이상의 피해가 발생하고 있으며, 벼 도열병의 경우, 5천만 톤 이상의 벼가 매년 폐기되는 피해를 보고 있습니다.

  • Nat. Commun.
  • 2024.03.12

• • 우종찬(University of Wyoming, 서울대학교)

    Interview

  • 정승미(University of Wyoming)

  • 최도일(서울대학교)

  • 박은숙(University of Wyoming)

  Attenuation of phytofungal pathogenicity of Ascomycota by autophagy modulators

  • Nat. Commun. Feb 29 2024, 15 (1) 1621 | https://doi.org/10.1038/s41467-024-45839-2

  • 2024.02
  • 생명과학

• • 윤석현(Harvard Medical School and Massachusetts General Hospital)

  All-natural-molecule, bioluminescent photodynamic therapy results in complete tumor regression and prevents metastasis

  • Biomaterials 2023 May;296:122079 | https://doi.org/10.1016/j.biomaterials.2023.122079

  • 2023.05

• • 정다현(중앙대학교)

  • 이희석(중앙대학교)

  Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor

  • Environ. Pollut. 2023 May 15;325:121437 | https://doi.org/10.1016/j.envpol.2023.121437

  • 2023.05

• • 이송이(Stanford University)

  Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells

  • Nat. Methods 2023 May 15 | https://doi.org/10.1038/s41592-023-01880-5

  • 2023.05

• • 오재호(연세대학교)

  • 황정호(연세대학교 기계공학과)

  • 임지석(영남대학교)

  • 변정훈(영남대학교)

  Size-classified monitoring of ATP bioluminescence for rapid assessment of biological distribution in airborne particulates

  • Biosens. Bioelectron. Available online 28 April 2023 | https://doi.org/10.1016/j.bios.2023.115356

  • 2023.04
  • 바이오·의료융합

• • 박정아(인하대학교병원, Memorial Sloan Kettering Cancer Center)

  Targeting tumor vasculature to improve antitumor activity of T cells armed ex vivo with T cell engaging bispecific antibody

  • J. Immunother. Cancer 2023 Mar;11(3):e006680 | http://dx.doi.org/10.1136/jitc-2023-006680

  • 2023.03

• • 이주곤(College of Medicine, Florida State University)

  Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction

  • Proc. Natl. Acad. Sci. USA 2023 Feb 7;120(6):e2212255120 | https://doi.org/10.1073/pnas.2212255120

  • 2023.02

• • 정윤(University of Illinois Urbana-Champaign)

  Soft hydrogel-shell confinement systems as bacteria-based bioactuators and biosensors

  • Biosens. Bioelectron. Volume 219, 1 January 2023, 114809 | https://doi.org/10.1016/j.bios.2022.114809

  • 2023.01
  • 생명과학

• • 심규환(Washington University School of Medicine)

  Cure of disseminated human lymphoma with [177Lu]Lu-ofatumumab in a preclinical model

  • J. Nucl. Med. 2022 Nov 10;jnumed.122.264816 | https://doi.org/10.2967/jnumed.122.264816

  • 2022.11

• • 윤석찬(부산대학교)

  • 천서영(가톨릭 의과대학)

  • 박상준(가톨릭 의과대학)

  • 김문석(가톨릭대학교 의과대학)

  • 구희범(가톨릭대학교 의과대학)

  Recent advances in optical imaging through deep tissue: imaging probes and techniques

  • Biomater. Res. 2022 Oct 22;26(1):57 | doi: 10.1186/s40824-022-00303-4

  • 2022.10
  • 바이오·의료융합

• • 유정선(The Hong Kong Polytechnic University (홍콩이공대학))

  Label-free metabolic imaging for sensitive and robust monitoring of anti-CD47 immunotherapy response in triple-negative breast cancer

  • J. Immunother. Cancer 2022 Sep;10(9):e005199. | doi: 10.1136/jitc-2022-005199

  • 2022.09
  • 의약학

• • 박순범(서울대학교 의과대학)

  • 조은아(울산대학교 의과대학/(주)프리즘씨디엑스)

  • 천정녀(서울대학교 의과대학 인체환경경계생물학연구소)

  • 김상엽(서울아산병원)

  • 전주홍(서울대학교 의과대학 생리학교실)

  Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells

  • Exp. Mol. Med. Published 23 August 2022 | https://doi.org/10.1038/s12276-022-00835-8

  • 2022.08
  • 의약학

• • 이동현(가톨릭대학교 의과대학)

  • 구희범(가톨릭대학교)

  Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

  • Bioact. Mater. Volume 8, February 2022, Pages 20-34 | https://doi.org/10.1016/j.bioactmat.2021.06.019

  • 2022.02
  • 바이오·의료융합

• • 박정아(Memorial Sloan Kettering Cancer Center)

  Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy

  • J. Immunother. Cancer Online issue publication September 08, 2021, 9:e003114 | doi: 10.1136/jitc-2021-003114

  • 2021.09

• • 허기준(한국기계연구원)

  • 고현식(세종대학교)

    Interview

  • 김상복(한국기계연구원)

  • 정재희(세종대학교)

  Enriched Aerosol-to-Hydrosol Transfer for Rapid and Continuous Monitoring of Bioaerosols

  • Nano Lett. Publication Date January 14, 2021 | https://doi.org/10.1021/acs.nanolett.0c04096

  • 2021.01
  • 바이오·의료융합
• 

  장원조

  Augusta University

  1. 논문관련 분야의 소개, 동향, 전망을 설명, 연구과정에서 생긴 에피소드 G protein-coupled receptors (GPCRs) are the largest group of transmembrane protein in the human genome and arguably the most successful group of pharmaceutical targets. Recent biophysical studies have shown that GPCRs are conformationally dynamic, and that agonists and G protein cooperatively promote an active conformation that leads to G protein activation and signaling. In contrast, inverse agonists promote an inactive receptor conformation that does not bind G protein and does not signal. In their unliganded basal state GPCRs generally favor an inactive conformation, although spontaneous adoption of active conformers can lead to constitutive signaling. As part of this conserved mechanism agonists promote receptor activation and the formation of transient active-state receptor-G protein complexes. Receptor-G protein complexes that form prior to agonist binding or receptor activation have also been described, but their properties and functional significance for signaling have remained largely unexplored. This paper has demonstrated that preassociation of 5-HT7 serotonin receptors with Gs heterotrimers is necessary for agonist-induced signaling. While both inverse agonist and inactive receptor mutations both stabilize inactive-state 5HT7-Gs complexes, these complexes dissociate in response to agonists, allowing formation of conventional agonist-5HT7-Gs ternary complexes and subsequent Gs activation. This inactive state complex is critical for full dynamic range of agonist-induced signaling, as 5-HT7 receptors spontaneously activate Gs variants that cannot form inactive-state complexes. For 5-HT7 receptors two distinct receptor-G protein complexes, one conventional ternary complex and the other an inverse-coupled binary complex, are required for agonist induced signaling. The conclusions of this study for the first time provide a well-defined, functional role of preassembly in cellular

  • Proc. Natl. Acad. Sci. USA
  • 2020.12.08

• • 김은혜(한양대학교)

  • 박상우(한국기초과학지원연구원)

  • 김윤규(울산대학교 의과대학)

  • 이경진(울산대학교 의과대학, 한양대학교)

  • 이성수(한국기초과학지원연구원)

  • 김영필(한양대학교)

  Self-luminescent photodynamic therapy using breast cancer targeted proteins

  • Sci. Adv. 11 Sep 2020: Vol. 6, no. 37, eaba3009 | DOI: 10.1126/sciadv.aba3009

  • 2020.09
  • 바이오·의료융합

• • 이신정(연세대학교 의과대학, Emory University School of Medicine)

  • 윤영섭(연세대학교 의과대학, Emory University School of Medicine)

  Enhanced Therapeutic and Long-Term Dynamic Vascularization Effects of Human Pluripotent Stem Cell?Derived Endothelial Cells Encapsulated in a Nanomatr

  • Circulation November 14, 2017, Volume 136, Issue 20 | https://doi.org/10.1161/CIRCULATIONAHA.116.026329

  • 2017.11
  • 의약학