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1 Interdisciplinary research

' Interdisciplinary research' 에 대한 통합검색결과 160건입니다.

한빛사160건

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Fauzan Syarif Nursyafi

금오공과대학교, Institute of Bioinformatics Indonesia

Drug induced cardiotoxicity remains an important challenge in drug development because a promising compound can fail when unexpected effects on cardiac ion channels appear during later stages of development. Computational cardiac safety assessment has traditionally focused heavily on hERG, but cardiac electrophysiology is controlled by several ion channels working together. In particular, hERG, Cav1.2, and Nav1.5 regulate different phases of the cardiac action potential. This means that evaluating only one channel can provide an incomplete picture of potential cardiac risk. This was the main motivation for developing Cardiosim Tox, a computational platform designed to predict both the risk of channel blockade and the potency of that blockade, represented by pIC50, across all three channels.
- Arch. Toxicol.
- 2026.08.18
- 성지용(서울대학교, 분당서울대학교병원)
- 정재호(연세대학교 의과대학)
Advancing genomics and integration of multi-omics for precision oncology using quantum machine learning
- npj Digit. Med. Jul 11 2026, | https://doi.org/10.1038/s41746-026-02982-y
- 2026.07
- 의약학
박진영

University of Connecticut

My research primarily focuses on developing biodegradable devices for distinct clinical applications. In our recent Science Advances paper: "Wireless knee joint monitoring using biodegradable single-ended pressure sensor in osteoarthritis management" (10.1126/sciadv.aec8210), we addressed the challenge of monitoring knee joint loading, which is a critical factor in osteoarthritis progression and cartilage healing.
- Sci. Adv.
- 2026.07.06
엠디 압둘라알파하드

순천향대학교

By combining coaxial electrospinning with laboratory cell-conditioning, we successfully developed a functional, small-diameter vascular graft that overcomes the typical clotting risks of synthetic implants. We engineered a core-shell fibrous structure using a strong polycaprolactone core for structural integrity and wrapped it in a cardiac extracellular matrix shell to provide crucial biological cues.
- Bioact. Mater.
- 2026.06.18
김예은

McGill University

PrimerWeaver is a free, browser-based tool designed to integrate primer design and quality control across a diverse array of molecular biology workflows within a single platform. Modern molecular cloning often requires researchers to manually transfer designs across fragmented, disparate applications, which can be error-prone.
- Nucleic Acids Res.
- 2026.05.21
남윤지

University of Miami

This study investigated the functional impact of the African ancestry?specific 44-bp deletion in ABCA7, a strong genetic risk factor for Alzheimer’s disease. We found that the truncated ABCA7 protein is stable and localizes to the ER and plasma membrane in transfected HEK cells. Using isogenic iPSC-derived neurons (wild-type, heterozygous, and homozygous deletion), we observed that neurons carrying the ABCA7 deletion exhibited increased lipid droplet accumulation and impaired mitochondrial health.
- Alzheimers. Dement.
- 2026.04.14
Thi Thu Trang Kieu

전북대학교

Our study investigates how exposure to atmospherically relevant artificial particulate matter (PM₂.?) contributes to lung cancer development, with a particular focus on the physiological role of the cellular prion protein (PrPC).
- Environ. Sci. Technol.
- 2026.03.31
[Editorial] Virtual lab of artificial intelligence agents accelerating nanobody design against SARS-CoV-2 variants
- Int. J. Biol. Sci. 2026; 22(2): 618-621 | https://doi.org/10.7150/ijbs.126093
- 2026.01
- 바이오·의료융합
이호현

Georgia Institute of Technology

This paper presents a data-driven, closed-loop focused ultrasound framework that enables more precise and reliable control of microbubble-mediated drug delivery in the brain. By combining acoustic emission monitoring with machine learning-assisted feedback, we demonstrate that microbubble dynamics can be regulated safely in real time during ultrasound exposure.
- Adv. Sci.
- 2026.01.23
Md Shohel Rana

경북대학교

Our study addresses the growing problem of diarrheal infections caused by multi-drug resistant Escherichia coli, particularly enterotoxigenic E. coli (ETEC). We introduce a dual-action therapeutic strategy combining bacteriophage therapy with bentonite, a natural clay mineral. While the phage EC.W2-6 efficiently eliminates bacterial populations, phage therapy in the gastrointestinal tract faces challenges such as acidic inactivation and the inflammatory release of toxins?specifically lipopolysaccharides (LPS) and outer membrane vesicles (OMVs)?during bacterial lysis.
- Biomater. Res.
- 2026.01.06
이애진

The Ohio State University, 명지대학교

This study builds directly on my previous first-author work published in Biomaterials (2020), in which I demonstrated that an amino acid-based compound, AAC2, improves glycemic control and anxiety-like behavior in diabetic mice through insulin-independent activation of the leptin receptor and atypical PKC pathways.
- J. Nanobiotechnol.
- 2026.01.05
Navnath S. Padalkar

중앙대학교

This study reports the design of a high-performance thin-film cathode material for hybrid supercapacitor devices using a synergistic strategy that combines high-entropy metal doping and molybdate anion intercalation in layered double hydroxide (LDH) nanosheets. A binder-free NiCoZnCrFe-LDH intercalated with molybdate anions was directly grown on stainless steel via a simple electrodeposition method.
- Small
- 2026.01.02
한누리

University of Zurich

This modelling study evaluated the long-term population-level impact of introducing long-acting cabotegravir and rilpivirine (CAB/RPV-LA) in South Africa. The model projected that generalized implementation of CAB/RPV-LA could substantially increase both integrase strand transfer inhibitor (INSTI) and rilpivirine drug resistance over time, compared with continued use of oral dolutegravir-based treatment.
- Lancet Glob. Health
- 2025.12.18
Christian Park

Georgia Tech and Emory University

Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), while those exposed to stable flow (s-flow) are protected. This study proposes and tests a two-hit hypothesis that d-flow initiates a partial flow-induced reprogramming of endothelial cells (FIRE), whereas full FIRE requires the combined stimuli of d-flow and hypercholesterolemia.
- Cardiovasc. Res.
- 2025.12.08
박미현

Technical University of Munich

Mass Spectrometry Imaging (MSI) encompasses a group of powerful imaging techniques that enable researchers to visualize the spatial distribution of hundreds of biomolecules directly within biological samples using mass spectrometry (MS). Unlike traditional bulk omics methods that average molecular signals and lose spatial information, MSI preserves the native tissue context by scanning the sample surface with an ionization source and recording a mass spectrum at each position.
- ACS Central Sci.
- 2025.11.12
Leveraging Blockchain and AI for Biofilm Control in Food Processing Environments
- Compr. Rev. Food. Sci. Food Saf. Sep 2025, 24 (5) | https://doi.org/10.1111/1541-4337.70261
- 2025.09
- 생명과학
배수경

연세대학교 의과대학 융합의학과

We developed a two-stage, multimodal AI framework to stratify the risk of Autism Spectrum Disorder (ASD) in toddlers aged 18-48 months. This study represents the first research outcome from a landmark large-scale national project in Korea, commissioned by the Ministry of Health and Welfare's National Center for Mental Health. It was conducted through a Seoul National University?Yonsei University consortium, using data from nearly 1,300 toddlers.
- npj Digit. Med.
- 2025.09.01
배한규

University of Michigan

SCN2A 유전자는 Voltage gated sodium channel 1.2 (Nav1.2)를 발현하는 유전자로, 다양한 신경발달장애(neurodevelopmental disorders)와 밀접한 관련이 있습니다. 특히 SCN2A의 기능 변화 양상에 따라 서로 다른 질환이 유발되는데, gain of function (GOF) 변이는 주로 간질(epilepsy)과 연관되어 있으며, loss of function (LOF) 변이는 자폐 스펙트럼 장애(ASD)와 밀접하게 관련되어 있는 것으로 알려져 있습니다.
- Nat. Commun.
- 2025.08.07
Niti Sharma

가천대학교

Recent cerebrospinal fluid (CSF) proteomic research categorized AD into five molecular subtypes with discrete genetic risk profiles. Subtypes 1-3, namely neuronal hyperplasticity, innate immune activation, and RNA dysregulation, were characterized by more classical AD-related changes, like accumulation of amyloid/tau, and synaptic and immune dysfunction.
- Alzheimers. Dement.
- 2025.07.31
Janbolat Ashim

DGIST

With the rise of industrialization and advancements in polymer chemistry, microplastics have become widespread in the environment over the past five decades. They’ve been found everywhere?from terrestrial soils and oceans to even remote areas like deserts and Antarctic ice.
- Environ. Sci. Technol.
- 2025.07.24