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통합검색

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1 Interdisciplinary research

' Interdisciplinary research' 에 대한 통합검색결과 156건입니다.

한빛사156건

최신순
관련도순

남윤지

University of Miami

This study investigated the functional impact of the African ancestry?specific 44-bp deletion in ABCA7, a strong genetic risk factor for Alzheimer’s disease. We found that the truncated ABCA7 protein is stable and localizes to the ER and plasma membrane in transfected HEK cells. Using isogenic iPSC-derived neurons (wild-type, heterozygous, and homozygous deletion), we observed that neurons carrying the ABCA7 deletion exhibited increased lipid droplet accumulation and impaired mitochondrial health.
- Alzheimers. Dement.
- 2026.04.14
Thi Thu Trang Kieu

전북대학교

Our study investigates how exposure to atmospherically relevant artificial particulate matter (PM₂.?) contributes to lung cancer development, with a particular focus on the physiological role of the cellular prion protein (PrPC).
- Environ. Sci. Technol.
- 2026.03.31
[Editorial] Virtual lab of artificial intelligence agents accelerating nanobody design against SARS-CoV-2 variants
- Int. J. Biol. Sci. 2026; 22(2): 618-621 | https://doi.org/10.7150/ijbs.126093
- 2026.01
- 바이오·의료융합
이호현

Georgia Institute of Technology

This paper presents a data-driven, closed-loop focused ultrasound framework that enables more precise and reliable control of microbubble-mediated drug delivery in the brain. By combining acoustic emission monitoring with machine learning-assisted feedback, we demonstrate that microbubble dynamics can be regulated safely in real time during ultrasound exposure.
- Adv. Sci.
- 2026.01.23
Md Shohel Rana

경북대학교

Our study addresses the growing problem of diarrheal infections caused by multi-drug resistant Escherichia coli, particularly enterotoxigenic E. coli (ETEC). We introduce a dual-action therapeutic strategy combining bacteriophage therapy with bentonite, a natural clay mineral. While the phage EC.W2-6 efficiently eliminates bacterial populations, phage therapy in the gastrointestinal tract faces challenges such as acidic inactivation and the inflammatory release of toxins?specifically lipopolysaccharides (LPS) and outer membrane vesicles (OMVs)?during bacterial lysis.
- Biomater. Res.
- 2026.01.06
이애진

The Ohio State University, 명지대학교

This study builds directly on my previous first-author work published in Biomaterials (2020), in which I demonstrated that an amino acid-based compound, AAC2, improves glycemic control and anxiety-like behavior in diabetic mice through insulin-independent activation of the leptin receptor and atypical PKC pathways.
- J. Nanobiotechnol.
- 2026.01.05
Navnath S. Padalkar

중앙대학교

This study reports the design of a high-performance thin-film cathode material for hybrid supercapacitor devices using a synergistic strategy that combines high-entropy metal doping and molybdate anion intercalation in layered double hydroxide (LDH) nanosheets. A binder-free NiCoZnCrFe-LDH intercalated with molybdate anions was directly grown on stainless steel via a simple electrodeposition method.
- Small
- 2026.01.02
한누리

University of Zurich

This modelling study evaluated the long-term population-level impact of introducing long-acting cabotegravir and rilpivirine (CAB/RPV-LA) in South Africa. The model projected that generalized implementation of CAB/RPV-LA could substantially increase both integrase strand transfer inhibitor (INSTI) and rilpivirine drug resistance over time, compared with continued use of oral dolutegravir-based treatment.
- Lancet Glob. Health
- 2025.12.18
Christian Park

Georgia Tech and Emory University

Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), while those exposed to stable flow (s-flow) are protected. This study proposes and tests a two-hit hypothesis that d-flow initiates a partial flow-induced reprogramming of endothelial cells (FIRE), whereas full FIRE requires the combined stimuli of d-flow and hypercholesterolemia.
- Cardiovasc. Res.
- 2025.12.08
박미현

Technical University of Munich

Mass Spectrometry Imaging (MSI) encompasses a group of powerful imaging techniques that enable researchers to visualize the spatial distribution of hundreds of biomolecules directly within biological samples using mass spectrometry (MS). Unlike traditional bulk omics methods that average molecular signals and lose spatial information, MSI preserves the native tissue context by scanning the sample surface with an ionization source and recording a mass spectrum at each position.
- ACS Central Sci.
- 2025.11.12
Leveraging Blockchain and AI for Biofilm Control in Food Processing Environments
- Compr. Rev. Food. Sci. Food Saf. Sep 2025, 24 (5) | https://doi.org/10.1111/1541-4337.70261
- 2025.09
- 생명과학
배수경

연세대학교 의과대학 융합의학과

We developed a two-stage, multimodal AI framework to stratify the risk of Autism Spectrum Disorder (ASD) in toddlers aged 18-48 months. This study represents the first research outcome from a landmark large-scale national project in Korea, commissioned by the Ministry of Health and Welfare's National Center for Mental Health. It was conducted through a Seoul National University?Yonsei University consortium, using data from nearly 1,300 toddlers.
- npj Digit. Med.
- 2025.09.01
배한규

University of Michigan

SCN2A 유전자는 Voltage gated sodium channel 1.2 (Nav1.2)를 발현하는 유전자로, 다양한 신경발달장애(neurodevelopmental disorders)와 밀접한 관련이 있습니다. 특히 SCN2A의 기능 변화 양상에 따라 서로 다른 질환이 유발되는데, gain of function (GOF) 변이는 주로 간질(epilepsy)과 연관되어 있으며, loss of function (LOF) 변이는 자폐 스펙트럼 장애(ASD)와 밀접하게 관련되어 있는 것으로 알려져 있습니다.
- Nat. Commun.
- 2025.08.07
Niti Sharma

가천대학교

Recent cerebrospinal fluid (CSF) proteomic research categorized AD into five molecular subtypes with discrete genetic risk profiles. Subtypes 1-3, namely neuronal hyperplasticity, innate immune activation, and RNA dysregulation, were characterized by more classical AD-related changes, like accumulation of amyloid/tau, and synaptic and immune dysfunction.
- Alzheimers. Dement.
- 2025.07.31
Janbolat Ashim

DGIST

With the rise of industrialization and advancements in polymer chemistry, microplastics have become widespread in the environment over the past five decades. They’ve been found everywhere?from terrestrial soils and oceans to even remote areas like deserts and Antarctic ice.
- Environ. Sci. Technol.
- 2025.07.24
나타니엘 카르페나

단국대학교

Our research aimed to address a long-standing challenge in hearing loss therapy: how to generate functional cochlear hair cells in the lab. These cells are responsible for converting sound vibrations into electrical signals that the brain can interpret. In humans, once these cells are damaged-due to aging, noise, or drugs-they do not regenerate.
- Theranostics
- 2025.04.28
Sana Abdul Khaliq

가천대학교 의과대학

In this study, we investigated how a protein called ARHGEF3 regulates fat cell (adipocyte) development and enlargement?two key processes involved in obesity. We discovered that ARHGEF3 plays a dual role: it helps fat cells grow in size through the YAP-RhoA signaling pathway, and it promotes their full differentiation by boosting the activity of PPARγ, a master regulator of fat cell development.
- J. Adv. Res.
- 2025.04.26
Khandoker Asiqur Rahaman

한국과학기술연구원

This study was a multi-year collaboration and investigation into thymosin β4 (Tβ4) and its peptide metabolites. It focuses on their transformation from biological byproducts to bioactive agents with therapeutic relevance. Specifically, we identified and characterized Ac-Tβ1-17, a naturally derived Tβ4 metabolite, and revealed its dual functionality...
- Bioact. Mater.
- 2025.04.10
Soyolsaikhan Odkhuu

전북대학교

This study provides novel insights into the neural mechanisms underlying cognitive impairments in first-episode schizophrenia spectrum disorders, contributing valuable knowledge to early-stage intervention research. These findings align with the journal's mission to advance the understanding of neurobiological factors in psychiatric disorders and offer potential pathways for future therapeutic approaches.
- Biol. Psychiatry
- 2025.04.03
An Vuong Quynh Pham

고려대학교

Our research paper worked on elucidating the contribution of dysfunctional blood vessels to manifestation of psoriasis. In this paper, we have shown that, in mural psoriatic lesions, pro-inflammatory cell abundance leads to compromising of blood vessel barrier hence its dysfunctionality.
- Redox Biol.
- 2025.03.04