We pursue data-driven science to understand the complexity of the brain and diseases that affect the nervous system. We are interested in observable and cell-intrinsic aspects of cell identity from a molecular systems-level perspective.

We observe the "phenome" through the lens of a microscope. We utilize various imaging technologies, molecular biology tools, and develop deep learning methods to intergrate multiomic, high-dimensional data. We work closely through clinical collaborations to bridge bench-to-bedside.

2012 – 2018 PhD, The Scripps Research Institute, USA

2008 – 2012 BSc/BAc, Yonsei University, UIC, South Korea

Oct 2024 – present   Assistant Professor, Department of Biological Sciences, KAIST, South Korea

2018 – 2024  Postdoctoral fellow, ETH Zurich, Switzerland

What makes each cell unique? Through the intricate coordiation  of biology across scales - genes, organelles, cell types, organs, tissues, and organisms - each cell has a role to play. How do different gene regulatory networks determine the plasticity and commitment of cell fate? 

Dysregulation of cellular development and loss of cell identity over time results in the manifestation of various neurological diseases. These include brain cancers, rare monogenic disorders, and neurodegeneration. How can we better understand and treat these diseases using a personalized approach?

Throughout history, discovery of fundamental biological processes happened by observing cellular processes across diverse organisms. Among ~8.7 million eukaryotic species, we are only beginning to understand the phenomic diversity at the single-cell level. What can we learn from evolution?

Weiss T, Lee S, Snijder B, Weller M.

Neuro Oncology. 2025 Jan 12;27(1):5-6. doi: 10.1093/neuonc/noae233

Wegmann R, Bankel L, Festl Y, Lau K, Lee S, Arnold F, Cappelletti V, Fehr A, Picotti P, Dedes KJ, Franzen D, Lenggenhager D, Bode PK, Zoche M, Moch H, Britschgi C, Snijder B.

Nature Communications. 2024 Oct 2;15(1):8544. doi: 10.1038/s41467-024-52694-8

Lee S*, Weiss T*, Bühler M, Mena J, Lottenbach Z, Wegmann R, Sun M, Bihl M, Augustynek B, Baumann SP, Goetze S, van Drogen A, Pedrioli P, Penton D, Festl Y, Buck A, Kirschenbaum D, Zeitlberger AM, Neidert MC, Vasella F, Rushing EJ, Wollscheid B, Hediger MA, Weller M, Snijder B.

Nature Medicine. 2024 Sep 20; doi: 10.1038/s41591-024-03224-y

Hale BD, Severin Y, Graebnitz F, Stark D, Guignard D, Mena J, Festl Y, Lee S, Hanimann J, Zangger NS, Meier M, Goslings D, Lamprecht O, Frey BM, Oxenius A, Snijder B.

Science. 2024 Jun 7;384(6700):eadh8697. doi: 10.1126/science.adh8967

Schmassmann P, Roux J, Buck A, Tatari N, Hogan S, Wang J, Mantuano NR, Wieboldt R, Lee S, Snijder B, Kaymak D, Martins TA, Ritz M, Shekarian T, McDaid M, Weller M, Weiss T, Laeubli H, Hutter G.

Science Translational Medicine. 2023 Jul 19; 15 (705). doi: 10.1126/scitranslmed.adf5302

Pfaendler R*, Hanimann J*, Lee S, Snijder B.

bioRxiv (pre-print). 2023 Jan 18. doi: 10.1101/2023.01.16.524226

Meister H, Look T, Roth P, Pascolo S Sahin U, Lee S, Hale BD, Snijder B, Regli L, Ravi VM, Heiland DH, Sentman CL, Weller M, Weiss T.

Clinical Cancer Research. 2022 Nov 01, 28(21):4747-4756, doi: 10.1158/1078-0432.ccr-21-4384

Conde, J, Pumroy RA, Baker C, Rodrigues T, Guerreiro A, Sousa BB, Marques MC, de Almeida B P, Lee S, Leites EP, Picard D, Samanta A, Vaz SH, Sieglitz F, Langini M, Remke M, Roque R, Weiss T, Weller M, … , Bernardes G.

ACS Central Science. 2021 May 26; 7(5):868-881. doi: 10.1021/acscentsci.1c00070

Buljan M, Ciuffa R, van Drogen A, Vichalkovski A, Mehnert M, Rosenberger G, Lee S, Varjosalo M, Pernas LE, Spegg V, Snijder B, Aebersold R, Gstaiger M.

Molecular Cell. 2020 Aug 6;79(3):504-520.e9. doi: 10.1016/j.molcel.2020.07.001

Tsunemoto R*, Lee S*, Szucs A, Chubukov P, Sokolova I, Blanchard JW, Eade KT, Bruggemann J, Sanna PP, Baldwin KK.

Nature. 2018 May 09; 557: 375-380. doi: 10.1038/s41586-018-0103-5

Blanchard JW*, Xie J*, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK.

Nature Biotechnology. 2017 Sep 11; 35: 960–968 doi: 10.1038/nbt.3963

Courchet J*, Lewis TL Jr*, Lee S, Courchet V, Liou DY, Aizawa S, Polleux F.

Cell. 2013 Jun 20; 153(7):1510-25. doi: 10.1016/j.cell.2013.05.021

PI : 이소현 교수 

MSc student : Paola Onate Colobon 

MSc/PhD Student : 현정아 

BSc student : 권도영 

Homepage : https://www.leelabkaist.org/

Contact : sohyonlee@kaist.ac.kr