브만사
>
BioLab
BioLab
인천대학교 생명나노바이오공학과 합성생물학·인공진화공학 연구실 Synthetic Biology and Evolutionary Bioengineering Lab.
장성호 교수
- 등록2025.04.14
- 조회816
연구실 소개
연구실 홈페이지Synthetic biology has the potential to provide solutions for the challenges of modern society and pave new ways to understand life. Our ability to design biological systems by synthetic biology is dependent on how to regulate gene expression. At Jang Laboratory, we integrate rational design and artificial evolution to create novel gene regulation systems for understanding fundamental biological processes and engineering valuable phenotypes. Particularly, we focus on nucleic acids that offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro. Using artificial gene regulators, we engineer microorganisms for improving energy, environment, and human health.
Keywords: synthetic genetic circuit, rational design, artificial evolution, aptamer, SELEX
Applications: microbiome engineering, gene therapy, molecular diagnosis, metabolic engineering, bioplastic
Sungho Jang, Ph.D. (장성호)
Assistant Professor, Incheon National University, South Korea
Experiences
2020.09 - Current. Assistant Professor, Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon, Korea
2019. 09. – 2020. 08. Postdoctoral Fellow, Department of Biomedical Engineering, Boston University, MA, US
2017. 03. – 2019. 08. Postdoctoral Research Associate, Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea
Educational Background
2010. 03. – 2017. 02. Ph.D. Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea
2006. 03. – 2010. 02. B.S. Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, Korea
연구분야
Synthetic biology has the potential to provide solutions for the challenges of modern society and pave new ways to understand life. Our ability to design biological systems by synthetic biology is dependent on our ability to regulate gene expression. At Jang Laboratory, we integrate rational design and artificial evolution to create novel gene regulation systems for understanding fundamental biological processes and engineering valuable phenotypes. Particularly, we focus on nucleic acids that offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro. Using artificial gene regulators, we engineer microorganisms for improving energy, environment, and human health.
Keywords: synthetic genetic circuit, rational design, artificial evolution, aptamer, SELEX
Applications: biosensor, microbiome engineering, metabolic engineering, molecular diagnosis
Synthetic Biology
Our group aims at (re)designing biological systems through rational engineering of genetic circuits mainly using nucleic acid-based gene regulators.
- - Dynamic gene regulators
- - Complex genetic circuits
Artificial Evolution
Our group is interested in developing synthetic biology tools for studying and accelerating the evolution of biomolecules and cells.
- - In vitro evolution (SELEX)
- - In vivo evolution
Applications
Our group is focusing on integrating Synthetic Biology and Artificial Evolution for applications in
- - Microbiome Engineering
- - Metabolic Engineering
- - Molecular Diagnosis
- - Biosensor
연구성과
최근 5년 (2021 ~ 현재 )
- Heonhae Min1+, Kyu-Sung Choi1+, Saebom Yun, Sungho Jang*. Live biotherapeutic products for metabolic diseases: development strategies, challenges, and future directions. Journal of Microbiology and Biotechnology (Accepted) (+ co-first authors, * corresponding author)
- Hyunjin Lee, Myung-Ji Seo*, Sungho Jang*. 1-Deoxynojirimycin-producing bacteria: production, optimization, biosynthesis, biological activities. (2024) Biotechnology and Bioprocess Engineering 29, 981-992 (* corresponding authors)
https://doi.org/10.1007/s12257-024-00159-6 - Jaeseong Hwang+, Dae-yeol Ye+, Gyoo Yeol Jung*, Sungho Jang*. Mobile genetic element-based gene editing and genome engineering: recent advances and applications. (2024) Biotechnology Advances 72, 108343 (* corresponding authors)
https://doi.org/10.1016/j.biotechadv.2024.108343 - Changhwan Hong+, Yoojin Kim+, Hyunjin Lee, Saebom Yun, Hyun Gyu Lim, Jina Yang*, Sungho Jang*. Vibrio species as next-generation chassis for accelerated synthetic biology. (2024) Biotechnology and Bioprocess Engineering (+ co-first authors, * corresponding authors)
https://doi.org/10.1007/s12257-024-00023-7 - Jeongho Lee, Hyeonmi Shin, Kang Hyun Lee, Hyeseon Lee, Giwon Lee, Sungho Jang, Gyoo Yeol Jung, Hah Young Yoo*, Chulhwan Park*. Component analysis and utilization strategy of brown macroalgae as promising feedstock for sugar platform-based marine biorefinery. (2024) Biotechnology and Bioprocess Engineering (* corresponding authors)
https://doi.org/10.1007/s12257-024-00022-8 - HG Hwang, A Milito, J-S Yang*, S Jang*, GY Jung*. Riboswitch-guided chalcone synthase engineering and metabolic flux optimization for enhanced production of flavonoids. (2023) Metabolic Engineering 75, 143-152 (* corresponding authors)
https://doi.org/10.1016/j.ymben.2022.12.006 - Y Xiu, N Zhang, P Prabhakaran, S Jang, Q Yuan, CM Breneman, GY Jung, W Vongsangnak, MAG Koffas. Parallel screening and cheminformatics modeling of flavonoid activated aptasensors. (2022) Synthetic and Systems Biotechnology 7(4), 1148-1158
https://doi.org/10.1016/j.synbio.2022.07.006 - MB Kim, S Hwangbo, S Jang, YK Jo. Bioengineered Co-culture of organoids to recapitulate host-microbe interactions. (2022) Materials Today Bio 16, 10034
https://doi.org/10.1016/j.mtbio.2022.100345 - M Kim, S Jang, GY Jung. Development of synthetic riboswitches to guide the evolution of metabolite production in microorganisms. (2022) Methods in Molecular Biology
https://doi.org/10.1007/978-1-0716-2421-0_9 - HG Hwang, MH Noh, MAG Koffas, S Jang*, GY Jung*. Multi-level rebalancing of the naringenin pathway using riboswitch-guided high-throughput screening. (2021) Metabolic Engineering 67, 417-427 (* corresponding authors)
https://doi.org/10.1016/j.ymben.2021.08.003 - H Lee, W Kim, S Jang, M-J Seo. Anti-Obesity and Anti-Inflammatory Effects of the Desalted Salicornia europaea L. Fermented by Bacillus velezensis K26. (2021) Food Engineering Progress 25(3), 169-177
http://db.koreascholar.com/article.aspx?code=409474 - Y Hwang*, SG Kim*, S Jang*, J Kim, GY Jung. Signal amplification and optimization of riboswitch-based hybrid inputs by modular and titratable toehold switches. (2021) Journal of Biological Engineering 15, 11 (* co-first authors)
https://doi.org/10.1186/s13036-021-00261-w
연구실 구성원
PI : 장성호 교수
Postdoctoral Fellow : 이현진, 최규성
PhD Student : 윤새봄 , 홍창환
Integrated MS/PhD Student : 김다솔, 김유진, 이승원
MS Student : 민현해, 홍현표
Research Intern : 오유정
Undergraduate Researcher : 김가연, 김동은, 양대규, 이성은, 이유민, 오현아, 정재상
Homepage : https://www.sjanglab.org
Contact : sjang@inu.ac.kr
하고싶은 이야기
인천대학교 합성생물학 · 인공진화공학 연구실에서 합성생물학, 인공진화공학, 마이크로바이옴, 대사공학, 분자진단 분야에서 연구할 학부 연구생, 대학원 신입생 및 박사후연구원을 상시 모집합니다. 전공분야에 큰 제약 없이 본 연구실의 연구 분야에 관심과 열정을 가진 분이라면 모두 지원 가능합니다. 연구분야, 연구실 생활, 진로 등 자세한 내용은 이메일 (sjang@inu.ac.kr)이나 전화 (032-835-8033)로 언제든 문의해 주십시오.
모집 전공: 생명공학, 화학공학, 신소재공학, 의공학, 생명과학, 생화학, 화학, 고분자공학, 전자공학, 컴퓨터공학 등
본 정보는 해당 기관에서 제공한 자료를 바탕으로 구성된 내용으로, BRIC에서 자체 생산한 정보가 아님을 밝혀드립니다.
소개된 내용에서 중요하게 판단되는 부분은 해당 기관에 추가적으로 사실 확인 작업을 하시길 부탁드립니다.
내용의 업데이트 또는 변경을 원하시면 관리자(interview@ibric.org)에게 연락 바랍니다.
