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BioLab
BioLab
Univ. of Hong Kong, Jung Kim LAB
김정 교수
- 등록2024.12.30
- 조회512
연구실 소개
연구실 홈페이지The Jung Kim lab focuses on this fundamental question, "How do tumors actually kill their hosts?".
Using simple and powerful Drosophila cancer models,we investigate the effects of tumor-induced systemic stress on host morbidity and mortality.
Using simple and powerful Drosophila cancer models,we investigate the effects of tumor-induced systemic stress on host morbidity and mortality.
Jung Kim, Ph.D. (김정)
Assistant Professor, School of Biomedical Sciences, Faculty of Medicine, University of Hong Kong
Education
2015 Ph.D. Genetics, Cell Biology and Development, University of Minnesota, USA
2009 M.S. Biotechnology and Genetic Engineering, Korea University, South Korea
2004 B.S. Biotechnology and Genetic Engineering, Korea University, South Korea
Experience
2022. 09 - present Assistant Professor School of Biomedical Sciences, University of Hong Kong
2015. 09 - 2022. 06 Postdoctoral researcher, Molecular and Cell Biology, University of California - Berkeley
2009. 08 - 2015. 08 Ph.D. student researcher, Genetics, Cell Biology and Development, University of Minnesota
2007. 03 - 2009. 02 M.S. student researcher, Biotechnology and Genetic Engineering, Korea University
연구분야
Effects of Systemic Inflammation on Host Morbidity and Mortality
The Jung Kim Lab is seeking to answer the fundamental question in cancer biology; "How do tumors actually kill hosts?"
Tumors disrupt host physiology locally and systemically. Locally, tumors damage adjacent host tissues via direct contact. Systemically, tumors release many factors including cytokines, hormones, and metabolites, which travel through the circulation and affect organs at a distance. These systemic effects are also called paraneoplastic syndromes or paraneoplasias, and the mechanisms underlying here are still unclear.
We mainly focus on the systemic effects of tumors caused by tumor-secreted cytokines or hormones. Tumors can disrupt host organs at a distance via systemic effects, also called paraneoplastic syndromes or paraneoplasias. Using powerful Drosophila models, we found that tumor-secreted cytokine, fly IL-6, disrupts the blood-brain barrier (BBB) in the brain, leading to host death. Furthermore, these exciting phenotypes are recapitulated in mice (Developmental Cell, 2021). Strikingly, blocking systemic inflammation caused by fly IL-6 partially rescued BBB damage as well as reduced lifespan, in both flies and mice.
This is the beginning of understanding the molecular and cellular mechanisms of paraneoplastic syndromes. The goal of the Jung Kim Lab is to figure out what the tumor-secreted factors are and their functions and targets.
연구성과
Selected Publications
Kwok S. H., Liu Y., Bilder D.*, & Kim J.* (2024) Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells. PNAS. 121(42):e2405860121. doi: 10.1073/pnas.2405860121. (*Co-corresponding authors)
Hsi T. C., Ong K., Sepers J. J., Kim J., & Bilder D. (2023) Systemic coagulopathy drives host lethality in a new Drosophila tumor model. Current Biology. 33, 3002-3010.
Kim J., Chuang H. C., Wolf N. K., Nicolai C. J., Raulet D. H., Saijo K., & Bilder D. (2021) Tumor-induced disruption of the blood-brain barrier promotes host death. Developmental Cell. 56, 2712-2721
Bilder D., Ong K., His T. C., Adiga K., & Kim J. (2021) Tumor-host interactions through the lens of Drosophila. Nature Reviews Cancer. 21, 687-700.
Kim J., Bilder D., & Neufeld T. P. (2018) Mechanical stress regulates insulin sensitivity through integrindependent control of insulin receptor localization. Genes & Development. 32, 156-164.
Kim J. & Neufeld T. P. (2015) Dietary sugar promotes systemic TOR activation in Drosophila through AKHdependent selective secretion of Dilp3. Nature Communications. 6, 6846.
연구실 구성원
지도교수 : 김정
현재 구성원
PhD Student : Renee KWOK, Yuchen LIU, Andreas LI
MPhil Student : Harold SY
Technical Officer : Tom SIT
Homepage : https://www.jungkimlab.com
Contact : jungkim@hku.hk
하고싶은 이야기
We are actively hiring!!!
We are looking for motivated students and researchers at all levels:
Research Assistant (RA)
Master of Philosophy (MPhil)
Doctor of Philosophy (PhD)
Post-doc
For any inquiries, please send your CV to Dr. Jung Kim:
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