Our research group (M2B Lab) focuses on the adverse outcomes of microplastics for invertebrates and the production of biomaterials from microalgal biomass. 

Sang-Ah Lee, Ph.D. (이상아)
Assistant Professor, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, KOREA

Education
2012 B.S. Chungbuk National University (CBNU)-"Major: Microbiology
2014 M.S. Chungnam National University (CNU)-"Major: Biodiversity & Environmental Ecology
2021 Ph.D. University of Science & Technology (UST)-"Major: Environmental Biotechnology

Professional Experience
2018 ~ 2021 Research Fellow: Korea Research Institute of Bioscience and Biotechnology, KRIBB
2021 ~ 2022 Postdoctoral Research Fellow: KIST-Europe forschungsgesellschaft mbh, KIST-Europe
2022 ~ 2023 Associate Researcher: Honam National Institute of Biological Resouces, HNIBR
2023 ~ Present Assistant Professor: Jeju National University, JNU

Research interest

1. Biomaterials & biotechnological process engineering
 - Microalgal biomass production process for the biodiesel raw materials
 - Carotenoid pigments, algal secondary metabolites, application to model organisms
 - Advanced microalgal wastewater treatment process engineering

2. Omics studies
 - A prediction-reproducibility study on environmental host-microbiota network analysis
 - Interpretation of multi-omics data on environmental science
 - Transcriptome (Daphnia, Zebrafish, and mammal cells)

 3. Adverse outcome effect on model organisms and mammal cell line
 - Effect of endocrine disruption effect on environmental models
 - The adverse outcomes evaluation of weathering microplastic in invertebrates
 - Computational prediction modeling for the intracellular response to chemicals

최근 4년, 2021~ 현재 

2024

Esterhuizen, M*, Monticelli M., Lee, S.-A., Kim, Y., Pflugmacher, S., Kim, Y. J., (2024): Oxidative stress status and antioxidative responses in neonate versus adult Daphnia magna exposed to polystyrene leachate. Toxicol. Environ. Health Sci. 1-9 I.F.-1.7 (Co-author)

Kim, J., Choi, H.-J., Seo, D., Lee, S.-A., Heo, J.B., Baek, D.H., Lee, W.**, Song, G. Y.*,(2024): Steamed ginseng berry powder ameliorates skeletal muscle atrophy via myogenic effects. J. Microbiol. Biotechnol. 34(1):157-166 I.F.-2.8 (Co-author)

Esterhuizen, M*, Lee, S.-A., Kim, Y., Järvinen, R., Kim, Y.J.(2024): Ecotoxicological consequences of polystyrene naturally leached in pure, fresh, and saltwater: lethal and nonlethal toxicological responses in Daphnia magna and Artemia salina. Frontiers in Marine Science. 11:1338872 I.F.-3.7 (1st author)

2023

Lee, S.-A., Ryu, C.S., Park, C.G., Cho, H., Jun, I., Park, C., Esterhuizen, M*., Kim, Y.J.(2023): Investigating the endocrine disruption effects of four disinfection byproducts on Zebrafish estrogen receptor-α. Frontiers in Marine Science. 10:1306130 I.F.-3.7 (1st author)

Esterhuizen, M.*, Lee, S.-A., Järvinen, R., Kim, Y., Pflugmacher, S., Kim, Y. J. (2023): Ecotoxicology of Polystyrene Microplastic Fragments: Oxidative Stress Effects in Neonate Versus Adult Daphnia magna. Water Air Soil Pollut. 234(11):713 I.F.-2.9 (1st author)

Lee, H.-J. †, Choi, H.-J. †, Lee, S.-A., Baek, D.H., Heo, J.B., Song, G.Y.*, Lee, W.*(2023): Myogenesis effects of RGX365 to improve skeletal muscle atrophy. Nutrients 15(19): 4307, I.F.- 5.9 (Co-author)

Kang, M., Le, V.V., Ko, S.-R., Lee, S.-A., Choi, D.-Y., Oh, H.-M., Ahn, C.-Y.*(2023): Novosphingobium cyanobacteriorum sp. nov., isolated from a eutrophic reservoir during the Microcystis bloom period. Int. J. Syst. Evol. Microbiol. 73(9): 006042, I.F.-2.8 (Co-author)

Kim, M. †, Lee, S.-A. †, Yun, J.-H., Ko, S.-R., Cho, D.-H., Kim, H. S., Oh, H.-M., Kim, H.-S., Ahn, C.-Y.*(2023): Cultivation of Chlorella sp. HS2 using wastewater from soy sauce factory. Chemosphere 342:140162, I.F.-8.8 (1^st author)

Deng, Y.-H., Jeon, J., Kim, E.M., Ding, S., Lee, S.-A., Ryu, C., Kim, Y.J., Su, X., Kong, H.*(2023): In situ immobilization of δ-MnO2 nanosheets on a porous support for rapid and continuous cleaning of bisphenol A-spiked water. Chem. Eng. J. 472: 144653, I.F.-15.1 (Co-author)

Lee, S.-A.†, Park, C.G.†, Esterhuizen, M., Choi, I., Ryu, C.S., Yang, J.H., Kim, Y.J.*(2023): Investigating endocrine disrupting impacts of nine disinfection byproducts on human and zebrafish estrogen receptor alpha. Front. Biosci. Landmark 28(3):48, I.F.-3.1 (1st author)

Jun, I., Cho, H., Amos, S.E., Choi, Y., Choi, Y.S., Ryu, C.S., Lee, S.-A., Han, D.-W., Han, H.-S., Yang, J.H., Jeong, H.-W., Park, H.*, Kim, Y.J.* (2023): Thyroid-friendly Soft Materials as Three-dimensional Cell Culture Tool for Stimulating Thyroid Cell Function. Small 19(25): 2300236 I.F.-13.3 (Co-author)

Le, V.V., Quynh-Giao, T., Ko, S.-R., Lee, S.-A., Oh, H.-M., Kim, H.-S.**, Ahn, C.-Y.* (2023): How do freshwater microalgae and cyanobacteria respond to antibiotics? Crit. Rev. Biotechnol. 43: 07388551, I.F.-9.0 (Co-author)

2022

Lee, S.-A.†, Kim, M.†., Kim, H.-S., C.-Y. Ahn.* (2022): Extra benefit of microalgae in raw piggery wastewater treatment: pathogen reduction. Microbiome 10, 142. I.F.-15.5 (1st author)

Cho, H.-K., Ryu, C. S., Lee, S.-A., Adeli, Z., Meupea, B.T., Kim, Y.*, Kim, Y.J. (2022): Endocrine-disrupting potential and toxicological effect of para-phenylphenol on Daphnia magna. Ecotoxicol. Environ. Saf. 243, 113965. I.F.-6.8 (Co-author)

Le, V.V., Ko, S.-R., Kang, M., Lee, S.-A., Oh, H.-M., Ahn, C.-Y.* (2022): The cyanobactericidal bacterium Paucibacter aquatile DH15 caused the decline of Microcystis and aquatic microbial community succession: A mesocosm study. Environ. Pollut. 311, 119849, I.F.-8.9 (Co-author)

Samadi, A., Kim, Y., Lee, S.-A., Kim, Y. J.**, Esterhuizen, M.*(2022): Review on the ecotoxicological impacts of plastic pollution on the fresh water invertebrates. Environ. Toxicol. I.F.-4.5 (Co-author)

Lee, S.-A.†, Kim, M.†, Esterhuizen, M., Le, V.V., Kang, M., Ko, S.-R., Oh, H.-M., Kim, Y.J.**, Ahn, C.-Y.* (2022): An acceleration of carotenoid production and growth of Haematococcus lacustris induced by host-microbiota network interaction. Microbiol. Res. 262, 127097. I.F.-6.7 (1st author)

Park, C. G., Jun, I., Lee, S., Ryu, C.S., Lee, S.-A., Park, J., Han, H.-S., Park, H., Manz, A., Shin, H.**, Kim, Y. J.* (2022): Integration of Bioinspired Fibrous Strands with 3D Spheroids for Environmental Hazard Monitoring. Small 18, 2200757. I.F.-13.3 (Co-author)

Le, V.V., Ko, S.-R., Kang, M., Lee, S.-A., Oh, H.-M., Ahn, C.-Y.* (2022): Panacibacter microcysteis sp. nov., isolated from a eutrophic reservoir during the Microcystis bloom period. Arch. Microbiol. 204, 291. I.F.-2.8 (Co-author)

Le, V.V., Ko, S.-R., Lee, S.-A., Kang, M., Oh, H.-M., Ahn, C.-Y.* (2022): Caenimonas aquaedulcis sp. nov., Isolated from Freshwater of Daechung Reservoir during Microcystis Bloom”. J. Microbiol. Biotechnol. 32: 1-10, I.F.-2.8 (Co-author)

Lee, S.-A., Lim, W.-H., Le, V.V., Ko, S.-R., Kim, B., Oh, H.-M., Ahn. C.-Y.* (2022): Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans, Bioresour. Technol. Rep. 17: 100962, Scopus Cite Score 6.3 (1st author)

Le, V. V., Ko, S.-R., Kang, M., Lee, S.-A., Oh, H.-M., Ahn, C.-Y.* (2022): Algicide capacity of Paucibacter aquatile DH15 on Microcystis aeruginosa by attachment and non-attachment effects. Environ. Pollut. 302, 119079, I.F.-8.9 (Co-author)

2021

Lee, S.-A., Ko, S.-R., Lee, N., Lee, J.-W., Le, V.V., Oh, H.-M., Ahn. C.-Y.* (2021): Two-step microalgal (Coelastrella sp.) treatment of raw piggery wastewater resulting in higher lipid and triacylglycerol levels for possible production of higher-quality biodiesel. Bioresour. Technol. 332: 125081, I.F.-11.4 (1st author)

Lee, S.-A., Le, V.V., Ko, S.-R., Lee, N., Oh, H.-M., Ahn. C.-Y.* (2021): Mucilaginibacter inviolabilis sp. nov. isolated from phycosphere of Haematococcus lacustris NIES144 culture”. Int. J. Syst. Evol. Microbiol. 71: 004668, I.F.-2.8 (1st author)

Le, V.V., Ko, S.-R., Lee, S.-A., Jin, L., Blom, J., Ahn, C.-Y., Oh. H.-M.* (2021): Cochlodiniinecator piscidefendens gen. nov., sp. nov., an algicidal bacterium against the ichthyotoxic dinoflagellate Cochlodinium polykrikoides. Int. J. Syst. Evol. Microbiol. 71: 005124, I.F.-2.8 (Co-author)

Ko, S.-R., Le, V.V., Jin, L., Lee, S.-A., Ahn, C.-Y., Oh. H.-M.* (2021): Mariniflexile maritimum sp. nov., isolated from seawater of the South Sea in Korea. Int. J. Syst. Evol. Microbiol. 71: 004925, I.F.-2.8 (Co-author)

Moon, G.S., Lee, N., Kang, S.S., Park, J.W., Kim, Y.E., Lee, S.-A., Chitumalla, R. K., Jang, J.K., Choe, Y.S., Oh. Y.-K.* (2021): Hydrothermal synthesis of novel two-dimensional α-quartz nanoplates and their applications in energy-saving, high-efficiency, microalgal biorefineries. Chem. Eng. J. 413: 127467, I.F.-15.1 (Co-author)

Lee, S.-A., Lee, N., Oh, H.-M., Ahn. C.-Y.* (2021): Stepwise treatment of undiluted raw piggery wastewater, using three microalgal species adapted to high ammonia”. Chemosphere 263: 127934, I.F.-8.8 (1st author)

Le, V.V., Ko, S.-R., Lee, S.-A., Jin, L., Ahn, C.-Y., Oh. H.-M.* (2021): Novosphingobium aquimarinum sp. nov., isolated from seawater. Int. J. Syst. Evol. Microbiol. 70: 5911-5917, I.F.-2.8 (Co-author)

지도교수 : 이상아

(2024년 현재)
Post-doctoral researcher : Ve Van Le
Ph.D. & Intergrated student : Mehwish Taj
M.S. Student : Nam-Ho Lee
Undergraduate students : Eun Bin Joa, Dongguk Song, Yejin Bu, Jieun Jeong

Homepage : https://sites.google.com/view/leesangah
Contact : leesa@jejunu.ac.kr

안녕하세요 국립제주대학교 생명자원과학대학 생명공학부 바이오소재전공 이상아 교수 연구실입니다. 

우리 연구실은 단세포성 식물인 미세조류가 지니고 있는 광합성 기작을 활용하여 미생물 기반 CCUS(carbon capture utilization & storage)를 연구하는 환경을 연구하는 생물공정 및 생물정보학연구실입니다. 

우리가 살고 있는 지구의 환경이 온난화로 인해 악화되어 가는 것을 뉴스에서가 아닌 몸소 느낄수 있는 시대가 되었습니다.  그리고 이 같은 변화된 환경은 인류의 생존과 직결되어 있습니다. 

따라서 M2B 연구실은 지구의 변화된 환경의 회복 탄력성을 연구하고 내용은 아래와 같이 정의합니다.

 1. 시멘트이산화탄소 공정에서 배출 되는 이산화탄소제어 생물공정 및 질소/황산화물 제어 목적 NGS 기반 미세조류-박테리아 컨소시엄 연구

 2. 인간 및 가축 폐수 처리 고도화 생물공정 연구

 3. 담수, 해수, 토양의 meta-genomic 환경 회복탄력성 연구

 4. 타겟 유용 생명자원의 genome, transcriptome 변화 분석을 통한 환경영향성 평가

 5. 미세조류 기반 항산화물질인 카로테노이드 색소, DHA, EPA 등 생합성 및 활용 연구

청정 지역 제주에서 인류와 환경을 위한 의미있는 연구를 진행하고 있으니, 많은 관심 부탁드리며, 관련 연구를 하고자 하시는 분은 언제나 지도교수 이메일로 컨택요청하시면 됩니다. 

지도교수 이상아 
E-mail : leesa@jejunu.ac.kr