암극복을 목표로 항암제 개발에 필요한 효능 및 독성을 평가하는 연구실입니다.
임상적으로 적용하기 위한 중개연구로 다양한 분야의 연구자들과 협업을 통해 통합적인 연구를 진행하고 있습니다.

  1) 이식암동물모델을 통한 효능평가시스템 개발
  2) 천연물질을 활용한 항암효능 극대화 전략 모색
  3) 성호르몬에 따른 항암효능 및 부작용 연구

 AI 기반의 화학물질 유해성 평가 예측 시스템 구축을 위한 컨소시엄을 구성하고 데이터 구축을 수행하고 있습니다.

   Prof. Joohee Jung(정주희)
   Associate Professor, College of Pharmacy, Duksung Women's University

   Education
    1994-1998 : 덕성여자대학교 약학과
    1998-2000 : 덕성여자대학교 약학과 석사(위생화학 전공)
    2001-2004 : Osaka University 약학과 박사(환경약학 전공)

   Experiences
    2012-현재 : 덕성여자대학교 약학과 교수
    2007-2012 : 서울아산병원, 아산생명과학연구소 박사후연구원
    2004-2007 : SANKEN, Osaka University PostDoc
    2001-2004 : Osaka University (Monbukagakusho Research Student)

항암효능 평가를 위한 이식암모델 구축

   - Ectopic xenograft model
   - Orthotopic xenograft model
   - Progressive metastasis model
   - Patient-derived xenograft model
   - Patient-derived organoid xenograft model

GPER를 매개로 한 항암전략

   - Anticancer effect of chrysin via GPER in pancreatic cancer
   - Anticancer effect of resveratrol via GPER in colon cancer
   - Anticancer effect of G1 via GPER in liver cancer

AI 기반의 화학물질 유해성 평가를 위한 데이터 구축

   - Chemical hazard evaluation
   - Establishment of chemical DB for deep learning
   - Data cleaning and data segmentation

2021년 ~ 현재

- 2023

Jin H, Koh M, Lim H, Yong HY, Kim ES, Kim SY, Kim K, Jung J, Ryu WJ, Choi KY, Moon A. Lipid raft protein florillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation. Int J Cancer, 2023, 1-14. https://doi.org/10.1002/ijc.34443

Kim N, Kwon J, Shin US, Jung J. Stimulatory anticancer effect of resveratrol mediated by G protein-coupled estrogen receptor in colorectal cancer. Biomol Ther, 2023, Accepted. 

- 2022

Oh S, Kwon HJ, Jung J. Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice. Tox Res, 2022, 38, 1-7. https://doi.org/10.1007/s43188-021-00100-6

Kwon HJ, Lee S, Lee HH, Cho H, Jung J, Korean red ginseng enhances immunotherapeutic effects of NK cells via eosinophils in metastatic liver cancer model. Nutrients, 2022, 14(1), 134. https://doi.org/10.3390/nu14010134 

Lim HK, Kwon HJ, Lee GS, Moon JH, Jung J, Chrysin-induced G protein-coupled estrogen receptor activation suppresses pancreatic cancer, Int J Mol Sci, 2022, 23(17), 9673. https://doi.org/10.3390/ijms23179673

Lee S, Lee GS, Moon JH, Jung J, Policosanol suppressess tumor progression in a gastric cancer xenograft model, Tox Res, 2022, 38(4), 567-575. https://doi.org/10.1007/s43188-022-00139-z

Lee S, Jung J, Role of aldehyde dehydrogenase 3A1 in cancer progression, Drug Targets and Ther, 2022, 1(1), 59-66. https://doi.org/10.58502/DTT.22.002

Kwon HJ, Oh JY, Lee KS, Lim HK, Lee J, Yoon HR, Jung J, Lipid profiles obtained from MALDI mass spectrometric imaging in liver cancer metastasis model, Int. J. Anal. Chem. 2022, 6007158. https://doi.org/10.1155/2022/6007158

- 2021

Lee S, Jung J. trans-Cinnamaldehyde-induced apoptosis in AGS cells. J Food Hygie Safety, 36(1), 100-104, 2021. https://doi.org/10.13103/JFHS.2021.36.1.100

Oh S, Jung J. Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs, Lab Animal Res, 37, 10, 2021. https://doi.org/10.1186/s42826-021-00087-z

Lim H, Koh M, Jin H, Bae M, Lee SY, Kim KM, Jung J, Kim HJ, Park SY, Kim HS, Moon WK, Hwang S, Cho NH, Moon A. Cancer-associated fibroblasts induce an aggressive phenotypic shift in non-malignant breast epithelial cells via interleukin-8 and S100A8, J Cellular Physiol, 21 Mar 2021.   http://doi.org/10.1002/jcp.30364

Lee S, Kim KM, Lee SY, Jung J, Estrogen aggravates tumor growth in a diffuse gastric cancer xenograft model. Pathol Oncol Res, 16 Apr, 2021. https://doi.org/10.3389/pore.2021.622733 

Kim ES, Nam SM, Song HK, Lee S, Kim KM, Lim HK, Lee H, Kang KT, Kwon YJ, Chun YJ, Park SY, Jung J, Moon A, CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity, Oncogene, 15 Mar, 2021. 

Takagi K, Somiya M, Jung J, Iijima M, Kuroda S, Polymerized albumin receptor of hepatitis B virus for evading the reticuloendothelial system, Pharmaceuticals, 25 Apr, 2021. https://doi.org/10.3390/ph14050408

Oh S, Kwon HJ, Jung J. Estrogen exposure causes the progressive growth of SK-Hep1-derived tumor in ovariectomized mice. Toxicol Res, 27 May, 2021. https://doi.org/10.1007/s43188-021-00100-6

Kwon J, Oh S, Park M, Kong JS, Lee S, Lee H, Kim Y, Kang KT, Shin US, Jung J, Advanced xenograft model with cotransplantation of patient-derived organoids and endothelial colony-forming cells for precision medicine. J Oncol, 2021, 1-9, 14 July, 2021. https://doi.org/10.1155/2021/9994535

지도교수: 정주희 교수

(2023년 현재)

 PhD course: 권희정, 홍성익, 임현경, 김나윤
 Master course: 이선용
 PostDoc: 이선이  

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