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BioLab

숙명여자대학교 생명시스템학부 유전자세포치료연구실 Gene and Cell Therapy Laboratory

이병철 교수

  • 등록2026.05.18
  • 조회715

연구실 소개

한빛사 연구실 홈페이지
유전자세포치료연구실은 첨단 의생명과학기술의 적용을 가속화하고, 관련 학문 분야의 진보에 기여함으로써 인류의 복지에 공헌하는 것을 목표로 합니다. 
이를 위해 줄기세포를 이용한 유전자치료법 개발과 세포치료제 효능 증강 연구를 진행하고 있습니다.

Byung-Chul Lee, DVM, Ph.D. (이병철) 
Assistant Professor, Division of Biological Sciences, Sookmyung Women's University, Seoul, Korea 

Experiences
2023. 03. – present  Assistant Professor, Division of Biological Sciences, Sookmyung Women’s University, Seoul, Korea 
2019. 10. – 2023. 02.  Postdoc fellow, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, USA 
2019. 03. – 2019. 06.  Postdoc fellow, Adult Stem Cell Research Center (ASCRC), College of Veterinary Medicine, Seoul National University, Seoul, Korea
 
Education
2012. 03. – 2019. 02.  Ph.D. in Veterinary Medicine (Stem cell biology), College of Veterinary Medicine, Seoul National University,  Seoul, Korea
2006. 03. – 2012. 02.  B.S. in Veterinary Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Korea 

연구분야

The Ultimate Goals of GCTL
  1.  - To alleviate suffering by accelerating the application of advanced technologies, thereby reducing pain for those in need.  
  2.  - To contribute to the advancement of fundamental scientific knowledge and understanding

1. Unraveling Genotoxic Mechanisms Induced by Gene Editing and Advancing Next-Generation Gene and Cell Therapies 

Elucidating the Mechanisms of Genotoxicity Mediated by Precision Gene Editing 
  •  - Molecular and cellular analysis of the DNA damage repair pathway, including the p53 superfamily, in hematopoietic stem cells following gene editing via CRISPR/Cas9-NHEJ knockout, CRISPR/Cas9-HDR knock-in, as well as next-generation gene editing techniques such as base-editing for single base conversion and PRIME editing.
  •  - Research on improving engraftment ability by inhibiting mechanisms of genotoxicity : Prediction and tracking of hematopoiesis in vivo and in vitro in hematopoietic stem cells treated with genotoxicity inhibitors. 

Development of Bone Marrow Organoid as an Alternative Model to Hematopoietic Stem Cell Transplantation 
  •  - Construction of bone marrow organoids that replicate bone marrow structures using an established protocol and iPSCs with enhanced osteogenic differentiation capability.
  •  - Verification of the presence and function of stromal cells, lumen-forming vasculature, and hematopoietic cells, as well as the reproduction of osteoid lineage. Additionally, examination of differentiation into lymphoid cells, smooth muscle cells, and adipocytes.
  •  - Transplantation of hematopoietic stem cells into bone marrow organoids to analyze the interactions between bone marrow constituent cells and hematopoietic stem cells, as well as the initial engraftment mechanisms.

Verification of the Efficacy of in vivo Gene Therapy by using Lipid Nanoparticles 
  •  - Apply gene editors via lipid nanoparticles to verify the efficiency of genetic material delivery and the effective delivery of packed genotoxicity suppression candidate substances. 
  •  - Set an ex vivo gene therapy model as a control group and conduct comparative studies with current gene therapy application methods. 
  •  - Verify the results derived from bone marrow organoids through comparative studies in animal models. 

2. Enhancement of the Therapeutic Ability of Mesenchymal Stem Cells against the Immune-mediated Disorders through Disease-specific Pretreatment 
Augmentation of Immunomodulatory Function of Mesenchymal Stem Cells by Disease-specific licensing
  •  - Verify the regulatory ability of enhanced function MSCs on Th1/17 cell differentiation and major cytokine production.
  •  - Analyze the regulatory ability of enhanced function MSCs on the secretion of Th1/17 cell-related cytokines. 

Verification of Intestinal Integrity and Anti-Inflammatory Effects
  •  - Study the restoration of permeability in intestinal epithelial cells through co-culture with enhanced function stem cells by assessing the expression of tight junction proteins  or adherens junction proteins .
  •  - Determine the anti-inflammatory effects on intestinal epithelial cells after co-culturing with licensed MSCs by analyzing pro-inflammatory cytokines such as IL-6, IL-8, IL-1β, and IL-17C.

연구성과

Selected Publications


(*contributed equally)
  • Lee BC*. Challenges and innovations in hematopoietic stem cell transplantation: Exploring bone marrow niches and new model systems. BMB Reports. 2024 Aug;57(8):352-362.

  • Shin D, Kim MJ, Chun S, Kim D, Lee C, Ahn KS, Jung E, Kim D, Lee BC, Hwang D, Kim Y, Yoon SS. Elucidation of molecular basis of osteolytic bone lesions in advanced multiple myeloma. Haematologica. 2024 Jul 1;109(7):2207-2218.

  • Park HS*, Lee BC*, Chae DH, Yu A, Park JH, Heo J, Han MH, Cho K, Lee JW, Jung JW, Dunbar CE, Oh MK, Yu KR. Cigarette smoke impairs the hematopoietic supportive property of mesenchymal stem cells via the production of reactive oxygen species and NLRP3 activation. Stem Cell Res Ther. 2024 May 20;15(1):145.

  • Lee BC*, Gin A*, Wu C, Singh S, Grice M, Mortlock R, Abraham A, Fan X, Zhou Y, Aljanahi A, Choi U, deRavin SS, Shin TH, Hong S, Dunbar CE. Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell. 2024 Apr 4;31(4):455-466. (Correspondence)

  • Lee BC*, Zhou Y*, Bresciani E, Ozkaya N, Dulau-Florea A, Carrington B, Shin TH, Baena V, Syed ZA, Hong SG, Zhen T, Calvo KR, Liu P, Dunbar CE. A RUNX1-FPDMM rhesus macaque model reproduces the human phenotype and predicts challenge to curative gene therapies. Blood. 2023 Jan 19;141(3):231-237.

  • Shin TH, Zhou Y, Chen S, Cordes S, Grice MZ, Fan X, Lee BC, AlJanahi AA, Hong SG, Vaughan KL, Mattison JA, Kohama SG, Fabre MA, Uchida N, Demirci S, Corat MAF, Métais JY, Calvo KR, Buscarlet M, Natanson H, McGraw KL, List AF, Busque L, Tisdale JF, Vassiliou GS, Yu KR, Dunbar CE. A Macaque Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Interventions. Blood. 2022 Oct 20;140(16):1774-1789.

  • Lee BC, Lozano RJ, Dunbar CE. Understanding and Overcoming Adverse Consequences of Genome Editing on Hematopoietic Stem and Progenitor Cells. Mol Ther. 2021;29(11):3205-3218.

  • AlJanahi AA, Lazzarotto CR, Chen S, Shin TH, Cordes S, Fan X, Jabara I, Zhou Y, Young DJ, Lee BC, Yu KR, Li Y, Toms B, Tunc I, Hong SG, Truitt LL, Klermund J, Andrieux G, Kim MY, Cathomen T, Gill S, Tsai SQ, Dunbar CE. Prediction and Validation of Hematopoietic Stem and Progenitor Cell Off-Target Editing in Transplanted Rhesus Macaques. Mol Ther. 2021;30(1):209-222.

  • Lee BC*, Lee JY*, Kim J*, Shin N, Yoo JM, Kang I, Kim JJ, Lee SE, Kim D, Choi SW, Hong BH, Kang KS. Oral administration of microbiome-friendly graphene quantum dots as therapy for colitis. 2d mater. 2021;8(2):025036.

  1. Lee BC*, Lee JY*, Kim J, Yoo JM, Kang I, Kim JJ, Shin N, Kim DJ, Choi SW, Kim D, Hong BH, Kang KS. Graphene quantum dots as anti-inflammatory therapy for colitis. Sci Adv. 2020;6(18):eaaz2630.

  3. Lee BC, Kim JJ, Lee JY, Kang I, Shin N, Lee SE, Choi SW, Cho JY, Kim HS, Kang KS. Disease-specific primed human adult stem cells effectively ameliorate experimental atopic dermatitis. Theranostics. 2019;9(12):3608.

  5. Lee BC*, Shin N*, Lee JY, Kang I, Kim JJ, Lee SE, Choi SW, Wester GA, Kang KS. MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu. Front Immunol. 2018;9:1078.

  7. Kang I*, Lee BC*, Choi SW*, Lee JY, Kim JJ, Kim BE, Kim DH, Lee SE, Shin N, Seo Y, Kim HS, Kim DI, Kang KS. Donor-dependent Variation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Response to Hypoxic Preconditioning and Amelioration of Limb Ischemia. Exp Mol Med. 2018;50(4):35.

연구실 구성원

PI : 이병철 교수 
연구교수 : 이혜진 
석박통합과정 : 최윤서
박사과정 : 박혜선
석사과정 : 이채연, 김수현
인턴 : 강하늘, 정소향, 김경서

하고싶은 이야기

생명과학 분야 연구에 열정을 가지고 GCTL에서 함께 할 박사후 연구원(오가노이드 배양, BI 분석), 석사/박사과정, 인턴 연구원을 모집 중입니다.




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