We investigate the molecular mechanisms underlying host-virus interactions and extracellular vesicle-mediated intercellular communication in infection and neurological disease.

We focus our research on how viruses reprogram host cellular systems, how intrinsic immune defenses restrict viral replication, and how extracellular vesicles shape systemic inflammation and brain pathology.

Through the interdisciplinary integration of virology, immunology, and vesicle biology, we ultimately aim to identify novel therapeutic targets by uncovering the fundamental principles that regulate viral pathogenesis and neuroinflammatory disorders.

2014 박사: Friedrich-Alexander-University Erlangen-Nürnberg, Ph.D., Molecular Virology, Cancer Biology

2008 석사: Ewha Womans University, M.S., Cancer Biology

2006 학사: Ewha Womans University, B.S. Life Sciences

2022. 03 – 현재: 서울시립대학교 생명과학과 조교수, 부교수

2021. 02 – 2022. 02: Institute of Molecular Virology, Ulm University, 주니어 그룹 리더

2020. 07 – 2020. 12: Department of Microbiology, Cleveland Clinic Florida, 연구 교수

2018. 05 – 2020. 06: Department of Microbiology, The University of Chicago, 박사 후 연구원

2016. 10 – 2018. 04: Universitätsklinikum Erlangen, 주니어 그룹 리더

2014 .03 – 2016. 09: Universitätsklinikum Erlangen, 박사 후 연구원

Our laboratory investigates the molecular and cellular mechanisms that control host-virus interactions and extracellular vesicle-mediated cellular communication during infection and disease. Our research focuses on understanding how viruses reprogram host cells, how host defense systems counteract infection, and how extracellular vesicles function as critical regulators of intercellular signaling across tissues, including the central nervous system.

Host-virus interactions represent a highly dynamic biological network in which viral entry, replication, and dissemination are counterbalanced by host sensing pathways, intrinsic restriction factors, and coordinated immune responses. At the same time, viruses have evolved sophisticated strategies to manipulate cellular pathways, evade immune surveillance, and reshape intracellular and extracellular communication systems.

A central focus of our research is the role of exosomes and other extracellular vesicles as active mediators of disease progression. We study how virus-induced alterations in vesicle biogenesis and cargo composition affect immune regulation, systemic inflammation, and neurovascular integrity. Extending beyond classical virology, we explore how extracellular vesicle–mediated signaling contributes to neurological and neurodegenerative disorders. 

Through hypothesis-driven, mechanistic research, we aim to identify the fundamental principles that determine viral pathogenesis, host defense, and vesicle-mediated intercellular communication in infectious and neurological diseases.

We study how virus-induced remodeling of extracellular vesicles affects viral spread, immune modulation, and neuroinflammation.

We identify intrinsic and induced host mechanisms that restrict viral replication and shape infection outcomes.

We examine how viruses manipulate immune sensing, trafficking networks, and stress responses to evade immune surveillance.

Jung-Hyun Lee, Stephan Schierer, Katja Blume, Jochen Dindorf, Sebastian Wittki, 

Wei Xiang, Christian Ostalecki, Nina Koliha, Stefan Wild, Gerold Schuler, Oliver, T. Fackler, Kalle Saksela, Thomas Harrer, Andreas S. Baur

EBioMedicine , 2016 , 6 , 103-113 , Link

Jung-Hyun Lee, Sebastian Wittki, Tanja Bräu, Florian S Dreyer, Kirsten Krätzel, Jochen Dindorf, Ian C D Johnston, Stefanie Gross, Elisabeth Kremmer, Reinhard Zeidler, Ursula Schlötzer-Schrehardt, Mathias Lichtenheld, Kalle Saksela, Thomas Harrer, Gerold Schuler, Maurizio Federico, Andreas S Baur

Molecular Cell , 2013 , 49(4) , 668-679, Link

Young-Hwan Song, Hyukhee Kim, Andreas S. Baur, Jung-Hyun Lee

Trends in Immunology , 2025 , Link 

Woosung Shim, Anjae Lee, Jung-Hyun Lee

Journal of Microbiology , 2024 , Link 

BMB Reports , 2023 , 56 , 335-340 , Link 

Qinya Xie, Caterina Prelli Bozzo, Laura Eiben, Sabrina Noettger, Dorota Kmiec, Rayhane Nchioua, Daniela Niemeyer, Meta Volcic, Jung-Hyun Lee, Fabian Zech , Konstantin M J Sparrer, Christian Drosten, Frank Kirchhoff

iScience , 2023 , 26(4) , 106395 , Link 

Jung-Hyun Lee , Lennart Koepke, Frank Kirchhoff, Konstantin M J Sparrer

Medical Microbiology and Immunology , 2023 , 212(2) , 125-131 , Link 

Jung-Hyun Lee, Christian Ostalecki, Timo Oberstein, Stefan Schierer, Elisabeth Zinser, Martin Eberhardt, Katja Blume, Bianca Plosnita, Lena Stich, Heiko Bruns, Roland Coras, Julio Vera-Gonzales, Manuel Maler, Andreas S Baur

EBioMedicine , 2022 , 77 , 103903 , Link 

GuanQun Liu*, Jung-Hyun Lee*, Zachary M. Parker, Dhiraj Acharya, Jessica J. Chiang, Michiel van Gent, William Riedl, Meredith E. Davis-Gardner, Effi Wies, Cindy Chiang & Michaela U. Gack

Nature Microbiology , 2021 , 6 , 467-478 , Link 

Yoo Jane Han, Jing Zhang, Jung-Hyun Lee, Jennifer M Mason, Olga Karginova, Toshio F Yoshimatsu, Qinyu Hao, Ian Hurley, Laia Paré Brunet, Aleix Prat, Kannanganattu V Prasanth, Michaela U Gack, Olufunmilayo I Olopade

Cancer Research , 2021 , 81(6) , 1540-1551 , Link 

PI : 이정현 교수

석·박사 통합과정 : 김혁희, 송영환

석사과정 : 이안재, 김희형, 나재민, 나경민

학· 석· 박사통합연계과정 : 김은지

학부인턴 : 박준서

Homepage : https://lifesci.uos.ac.kr/jhlab_vil

Contact : jhlee1@uos.ac.kr 

우리 연구실은 빠른 결과보다 연구 문제를 명확히 설정하는 능력을 중요하게 생각합니다. 그러나 연구가 사고에만 머무르지 않고 의미 있는 결과로 이어지는 것 또한 과학자의 중요한 소양이라고 믿습니다. 실험이 잘 되지 않는 시간은 피해야 할 부분이 아니라 사고가 깊어지는 시기이지만 그 고민은 결국 다음 단계의 실험과 결과로 연결되어야 합니다.

연구는 혼자 하는 작업처럼 보이지만 실제로는 끊임없는 소통과 신뢰 위에서 이루어집니다. 자신의 데이터를 책임지고 끝까지 완성하려는 태도, 그리고 동료의 연구를 존중하며 함께 성장하려는 자세를 무엇보다도 중요하게 생각합니다. 완벽함보다는 성실함과 지속성을, 단기 성과보다는 작더라도 스스로 설계하고 마무리한 연구 경험을 더 높이 평가합니다.

우리 연구실에서는 모든 연구자가 자신만의 프로젝트를 책임지고 이끌며, 그 결과를 논문이나 학위로 완결하는 과학자로 성장하길 기대합니다. 프로젝트의 질문 설정부터 실험 설계, 해석, 정리까지의 전 과정을 경험하는 것은 필수적인 훈련이라고 생각합니다.

지도교수로서 저는 정답을 미리 제시하기보다 연구의 방향과 속도를 함께 점검하며 스스로 판단할 수 있도록 돕고자 합니다. 연구 과정에서의 시행착오와 고민은 성장의 일부이지만 목표를 향해 꾸준히 전진하는 과정 역시 중요하게 관리합니다.

바이러스 감염, 면역 반응, 세포외소포체, 그리고 신경질환을 아우르는 우리의 연구는 분명히 복잡하고 도전적입니다. 그러나 각 연구자가 하고자 하는 연구 목표를 세우고 하나의 프로젝트를 완성해 나갈 수 있도록 지원합니다. 스스로 사고할 수 있고, 결과로 말하는 과학자로 성장하고 싶은 분이라면 언제든 환영합니다.