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조회316

한양대학교 ERICA

Gut Microbes, 22 Dec 2025 | https://doi.org/10.1080/19490976.2025.2606477 Impact of gut microbiota on host stem cells across the gastrointestinal tract

Haengdueng Jeong ¹, Yura Lee ², Ki Taek Nam^{2 *}

¹Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea.
²Department of Biomedical Sciences, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Kore

^*Corresponding author: correspondence to Ki Taek Nam

Abstract

The gut microbiota plays a pivotal role in maintaining gastrointestinal (GI) homeostasis by influencing epithelial integrity, immunity, and metabolism. Recent studies have uncovered that gut microbiota can directly or indirectly modulate the behavior and function of adult stem cells across the GI tract, which are essential for tissue regeneration and disease prevention. Moreover, key microbial metabolites including short-chain fatty acids (SCFAs), tryptophan-derived indoles, succinate, secondary bile acids, and retinoic acid exert diverse effects on stem cell quiescence, proliferation, and differentiation. This review provides current knowledge on the interaction between gut microbiota and host stem cells in the stomach, intestine, and colon.

논문정보

형식Review Paper
게재일2025년 12월 (BRIC 등록일 2025-12-23)
연구진국내 연구진
분야 생명과학 > 생리학

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