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조회26

PengYu ZhangPengYu Zhang

전북대학교

Phytomedicine, Available online 26 November 2025, 157620 ｜https://doi.org/10.1016/j.phymed.2025.157620 Laminaria japonica extract alleviates fine particulate matter-exacerbated allergic rhinitis by inhibiting NLRP3-mediated pyroptosis and restoring epithelial barrier function

PengYu Zhang ^a, JiaYing Bao ^b, ChenYu Yuan ^c, Hyun-Jin Kim ^d,e, Hee Soon Shin ^f,g, Zhen Nan Yu ^h, Ok Hee Chai ^a,i

^aDepartment of Anatomy, Jeonbuk National University Medical School, Jeonju, 54896, Jeonbuk, Republic of Korea
^bDepartment of Microbiology, Jeonbuk National University Medical School, Jeonju, 54896, Jeonbuk, Republic of Korea
^cSchool of Pharmacy, Jeonbuk National University, Jeonju, 54896, Jeonbuk, Republic of Korea
^dDivision of Applied Life Science (BK21 Four), Department of Food Science and Technology, Institute of Agriculture and Life Science, Gyeongsang National University, 501 Jinjudaero, Jinju 52828, Korea
^eEZmass. Co., Ltd., 501 Jinjudaero, Jinju 55365, Korea
^fDivision of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea
^gFood Biotechnology Program, Korea University of Science and Technology, Daejeon, 305-350, Republic of Korea
^hCenter of Disease Immunity and Intervention, College of Medicine, Lishui University, Lishui 323000, China
ⁱInstitute for Medical Sciences, Jeonbuk National University, Jeonju, 54896, Jeonbuk, Republic of Korea

Correspondence: Zhen Nan Yu, MD.Ph.D., Ok Hee Chai, Ph.D.

Abstract

Background
Allergic rhinitis (AR) is a common chronic inflammatory disease, and environmental pollution, especially fine particulate matter (PM2.5), is an important exacerbating factor that induces inflammation, disrupts the epithelial barrier, and triggers pyroptosis. Pyroptosis has been shown to play a critical role in epithelial damage and inflammatory responses. Therefore, regulating pyroptosis and repairing the epithelial barrier may provide new strategies for the treatment of AR.

Purpose
Laminaria japonica has potent anti-inflammatory, antioxidant, and immunomodulatory properties. We investigated the protective effects and mechanisms of Laminaria japonica extract (LJE) on PM2.5-exacerbated AR in mice.
Study design and methods
The AR model was established in mice by OVA sensitization combined with PM2.5 exposure. After intervention with different doses of LJE, behavioral symptoms, serum IgE levels, cytokine expression in nasal lavage fluid and histopathological changes in nasal, intestinal, and splenic tissues were evaluated. Additionally, the expression of NLRP3 inflammasome-related proteins and epithelial barrier-related proteins was detected.

Results
LJE significantly alleviated nasal and intestinal symptoms, reduced the levels of anti-OVA IgE and IgG1, pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α and the histopathological damages of nasal, colon and spleen tissues. Also, LJE modulated the balances of Th1/Th2 and Treg/Th17, inhibited NF-κB/MAPK signaling pathway. Furthermore, LJE suppressed NLRP3-mediated pyroptosis by downregulation of caspase-1 p20 and IL-1β and restored epithelial barrier integrity in both nasal and colon tissues via up-regulating the expression of E-cadherin and occludin and down-regulating the expression of N-cadherin.

Conclusion
LJE may have therapeutic potential for AR by regulating NLRP3-mediated pyroptosis and restoring epithelial barrier integrity through NF-κB/MAPK signaling pathway in allergic responses.

논문정보

형식Research article
게재일2025년 11월 (BRIC 등록일 2025-12-10)
연구진국내(교신)+국외 연구진
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