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Phytomedicine, Volume 150, January 2026, 157619 | https://doi.org/10.1016/j.phymed.2025.157619
Multi-target mechanisms of Bojungikki-tang in psoriasis-like dermatitis: Integrative network and transcriptomic analysis
Yun Hee Kim a,1, Hye Jin Kim a,1, Hyun-Kyung Song b, Youn-Hwan Hwang a,c, Yu Jin Kim a, Seol Jang a, Bu-Yeo Kim a, Taesoo Kim a
aKMConvergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea
bPractical Research Division, Honam National Institute of Biological Resources, Gohadoan-gil 99, Mokpo58762, South Korea
cKorean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST), Daejeon 34054, South Korea
1These authors contributed equally to this work.
Corresponding authors: Bu-Yeo Kim, Taesoo Kim
aKMConvergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea
bPractical Research Division, Honam National Institute of Biological Resources, Gohadoan-gil 99, Mokpo58762, South Korea
cKorean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST), Daejeon 34054, South Korea
1These authors contributed equally to this work.
Corresponding authors: Bu-Yeo Kim, Taesoo Kim
Abstract
Background
Psoriasis is a chronic and complex disease characterized by itching, burning, and soreness with scaly plaques and erythematous lesions. It is associated with various comorbidities, such as rheumatoid arthritis, cardiovascular disease, and psychiatric complications. Psoriasis is a systemic inflammatory disease that increases the release of pro-inflammatory cytokines from chronically-activated innate and adaptive immune systems. To treat multifactorial and complex diseases, system-oriented drug design and drug combinations for synergistic effects are highly effective and advantageous. Previous studies have revealed the immunomodulatory effects of Bojungikki-tang (BJT, Buzhong-Yiqi-Tang in traditional Chinese medicine and Hochu-ekki-to in Kampo medicine) in complex diseases; however, the effect of BJT on psoriasis, a chronic autoimmune disease, has not been evaluated.
Psoriasis is a chronic and complex disease characterized by itching, burning, and soreness with scaly plaques and erythematous lesions. It is associated with various comorbidities, such as rheumatoid arthritis, cardiovascular disease, and psychiatric complications. Psoriasis is a systemic inflammatory disease that increases the release of pro-inflammatory cytokines from chronically-activated innate and adaptive immune systems. To treat multifactorial and complex diseases, system-oriented drug design and drug combinations for synergistic effects are highly effective and advantageous. Previous studies have revealed the immunomodulatory effects of Bojungikki-tang (BJT, Buzhong-Yiqi-Tang in traditional Chinese medicine and Hochu-ekki-to in Kampo medicine) in complex diseases; however, the effect of BJT on psoriasis, a chronic autoimmune disease, has not been evaluated.
Purpose
We evaluated the effect of BJT against psoriasis and the underlying mechanisms.
Methods
The anti-psoriatic effects of BJT were evaluated in vivo, and the underlying mechanisms were elucidated through network analysis, transcriptomics, UPLC–ESI–MS/MS, and molecular docking.
Results
In vivo studies confirmed that BJT reduced TNF-α, IL-1β, IL-6, Th17 cytokines, prostaglandin E2 production, and keratinocyte proliferation. Moreover, BJT regulated the expression of PLA2G4D, an enzyme of the arachidonic acid (AA) pathway, as well as other enzymes involved in this pathway, including COX-2.
Conclusion
This study demonstrated that BJT ameliorated psoriasis-like inflammation by concurrently regulating pivotal pro-inflammatory cytokines and two distinct steps of the AA pathway, which may be related to its multi-component composition. These findings indicate the therapeutic potential of the multi-component drug BJT on multiple targets for psoriasis-like inflammation.
논문정보
- Research article
- 2026년 01월 (BRIC 등록일 2025-12-02)
- 국내 연구진
- 의약학 > 한의학
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