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J. Nanobiotechnol., Nov 03 2025, 23 (1) | https://doi.org/10.1186/s12951-025-03781-5
Nanocorona-engineered gold nanostars orchestrate photothermal augmented immunotherapy and durable cancer vaccination
Jun Young Park1,2, Su Hyun Lim1, Gayeon Kim3, Jun-Young Park4, Byung-Gil Lee1,2,5, Sung Jean Park6*, Youngki Lee2* and Dongwoo Khang1,2,7*
1Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, South Korea
2Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, South Korea
3College of Medicine, Gachon University, Incheon 21999, South Korea
4Department of Biochemistry, Chungbuk National University, Cheongju 28644, South Korea
5Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, South Korea
6College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, South Korea
7Department of Physiology, College of Medicine, Gachon University, Incheon 21999, South Korea
Corresponding authors
Correspondence to Sung Jean Park, Youngki Lee or Dongwoo Khang.
1Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, South Korea
2Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, South Korea
3College of Medicine, Gachon University, Incheon 21999, South Korea
4Department of Biochemistry, Chungbuk National University, Cheongju 28644, South Korea
5Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, South Korea
6College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, South Korea
7Department of Physiology, College of Medicine, Gachon University, Incheon 21999, South Korea
Corresponding authors
Correspondence to Sung Jean Park, Youngki Lee or Dongwoo Khang.
Abstract
Protein coronas inevitably cloak nanoparticles in vivo, yet their therapeutic potential remains largely untapped. Here we engineer a single-protein nanocorona by adsorbing immunoglobulin G onto PEGylated gold nanostars and reveal a dual-mode antitumor strategy that couples innate and adaptive immunity. Nanocorona formation remodels β-sheets and α-helices secondary structure in IgG and reprograms tumor-associated macrophages toward an M1 phenotype, releasing pro-inflammatory cytokines. Leveraging the photothermal property of the AuS, near-infrared irradiation synergistically induces immunogenic cell death, lowers interstitial fluid pressure, and drives deep infiltration of cytotoxic T lymphocytes while depleting regulatory T cells. In syngeneic CT26 tumor models, the combined nanocorona and photothermal regimen with anti-PD-L1 destroys established tumors significantly and confers complete protection on rechallenge, indicating vaccine-like immune memory. Comprehensive hematology and organ histology show negligible systemic toxicity. These findings position single-protein nanocoronas as stand-alone immunotherapeutics and provide a generalizable blueprint for converting photothermal nanomaterials into multifunctional cancer vaccines.
논문정보
- Research article
- 2025년 11월 (BRIC 등록일 2025-11-03)
- 국내 연구진
- 의약학 > 종양의학
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