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Michigan State University

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Cancer Discov., Oct 06 2025, 15 (10) | https://doi.org/10.1158/2159-8290.CD-25-1112 Extrachromosomal DNA: A Trusted Path to Tumor Heterogeneity

Emmanuel E Korsah ^{1 †}, Noah A Dusseau ^{1 †}, Eunhee Yi ^{2 *}

¹Department of Physiology, College of Natural Science, Michigan State University, East Lansing, Michigan.

²Department of Physiology, College of Human Medicine, Michigan State University, East Lansing, Michigan.

^†These authors contributed equally

^*Corresponding author: correspondence to Eunhee Yi

Abstract

Extrachromosomal DNA (ecDNA) has been suggested as a key factor of tumor heterogeneity at the genomic and transcriptional levels, via unequal segregation and ecDNA hub formation, respectively. In this issue of Cancer Discovery, two studies further expand our understanding of the roles of ecDNA in enhancing tumor heterogeneity at the phenotypic and spatiotemporal levels, as well as in providing a strong selective advantage during tumor evolution. See related article by Montuori et al., p. 2054 See related article by Noorani et al., p. 2078.

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형식In the Spotlight
게재일2025년 10월 (BRIC 등록일 2025-10-08)
연구진국외 연구진
분야 의약학 > 분자세포의학

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