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Adv. Healthc. Mater., Sep 22 2025, | https://doi.org/10.1002/adhm.202503622
A Hierarchically Structured, Stretchable, Anti-Biofouling Encapsulation for Biodegradable Electronics
Won Bae Han 1 2 †, Sungkeun Han 1 †, Gwan-Jin Ko 1 3, Ulziituya Batjargal 4 5, Wonjun Jang 4 5, Venkata Ramesh Naganaboina 6, Han-Jun Kim 4 5 7 *, Suk-Won Hwang 1 8 9 *
1KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
2School of Electronic Engineering, Kyonggi University, Suwon, Gyeonggi-Do, 16227, Republic of Korea.
3Display Research Center, Samsung Display, Gyeonggi-Do, 17113, Republic of Korea.
4Interdisciplinary Major Program in Innovative Pharmaceutical Sciences, Korea University, Sejong, 30019, Republic of Korea.
5College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
6Department of Electronics and Communication Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Amaravati Campus, Andhra Pradesh, 522503, India.
7Department of Plastic and Reconstructive Surgery, College of Medicine, Amrita Vishwa Vidyapeetham, Korea University, Seoul, 02841, Republic of Korea.
8Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
9Department of Integrative Energy Engineering, Korea University, Seoul, 02841, Republic of Korea.
2School of Electronic Engineering, Kyonggi University, Suwon, Gyeonggi-Do, 16227, Republic of Korea.
3Display Research Center, Samsung Display, Gyeonggi-Do, 17113, Republic of Korea.
4Interdisciplinary Major Program in Innovative Pharmaceutical Sciences, Korea University, Sejong, 30019, Republic of Korea.
5College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea.
6Department of Electronics and Communication Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Amaravati Campus, Andhra Pradesh, 522503, India.
7Department of Plastic and Reconstructive Surgery, College of Medicine, Amrita Vishwa Vidyapeetham, Korea University, Seoul, 02841, Republic of Korea.
8Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
9Department of Integrative Energy Engineering, Korea University, Seoul, 02841, Republic of Korea.
†W.B.H. and S.H. equally contributed to this work.
*Corresponding authors: correspondence to Han-Jun Kim or Suk-Won Hwang
*Corresponding authors: correspondence to Han-Jun Kim or Suk-Won Hwang
Abstract
Biodegradable polymers have been employed as encapsulants for transient, resorbable implantable devices due to moderate water permeability, mechanical flexibility, and biocompatibility, however most of them relatively lack inherent anti-biofouling properties. This limitation can lead to undesired protein adsorption, cell adhesion, and fibrotic encapsulation, compromising device function and biocompatibility, particularly for long-term implantation scenarios. Here, this study introduces a soft, stretchable, and anti-biofouling encapsulant engineered by integrating self-assembled organosilicon nanowire networks onto micropatterned biodegradable elastomers. The resulting hierarchical surface architecture imparts superhydrophobicity while preserving mechanical integrity, improving water barrier performance by up to 420% compared to unmodified films and retaining stability under cyclic strains. Integration into a transient, stretchable optoelectronic device enables prolonged operation in aqueous environments, and in vitro and in vivo evaluations demonstrate suppressed cell adhesion, reduced fibrotic tissue formation, and excellent biocompatibility, highlighting the potential for long-lasting, bioresorbable electronic implants.
논문정보
- Research article
- 2025년 09월 (BRIC 등록일 2025-09-24)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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