조경아 (전남대학교 의과대학, 메디스팬) | 한빛사논문 > 한빛사

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조경아Kyung A Cho

전남대학교 의과대학, 메디스팬

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Exp. Mol. Med., 01 September 2025 | https://doi.org/10.1038/s12276-025-01527-9 Targeting immunosenescence and inflammaging: advancing longevity research

Thi Quynh Trang Nguyen ^1,2 and Kyung A Cho ^1,2,3,*

¹Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Republic of Korea.
²Center for Creative Biomedical Scientists, Chonnam National University Medical School, Hwasun-gun, Republic of Korea.
³MediSpan Inc., Bundang-gu, Republic of Korea.

^*Corresponding author: correspondence to Kyung A Cho

Abstract

Here we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various factors that lead to immune aging while introducing therapeutic approaches that can partially restore immune function. Additionally, we discuss recent strategies that go beyond localized immune improvement to actively modulate immune balance, influencing systemic aging and extending healthspan. Through this exploration, we propose that regulating the immune system is essential for managing immune aging and may serve as a key mechanism for controlling the overall aging process and promoting healthy longevity.

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