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Trends Cancer, Aug 26 2025, S2405-8033(25)00202-X | https://doi.org/10.1016/j.trecan.2025.08.004 [Forum] Leveraging phagocytosis using nanomedicines for cancer immunotherapy

Susam Lee ^1,4, Hoyeon Nam ^1,4, Katelyn Wahl ², Heewon Park ¹, DaeYong Lee^2,3

¹Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
²Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA
³Department of Biomedical Engineering, Virginia Tech, Blacksburg, VA, USA

⁴These authors contributed equally

Correspondence: DaeYong Lee

Abstract

Phagocytosis upregulation plays a crucial role in bridging to adaptive immunity for cancer immunotherapy. However, current approaches to modulating phagocytosis are beneficial to certain types of cancer only. In this Forum paper, we will highlight how nanoengineering can overcome the current limitation of phagocytosis-mediated cancer immunotherapy.

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