이승원 (성균관대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회189

성균관대학교 의과대학

CV File

Ophthalmology, Jul 28 2025, S0161-6420(25)00453-1 | https://doi.org/10.1016/j.ophtha.2025.07.019 Risk of depression in persistent blue light deprivation following cataract surgery: a population-based cohort study

Jihei Sara Lee M.D. ^{1 #}, Sunyeup Kim B.Sc. ^{2 #}, Chan Yun Kim M.D., Ph.D. ¹, Eun Hye Jung M.D. ¹, Hyoung Won Bae M.D., Ph.D. ¹, Sung Soo Kim M.D., Ph.D. ¹, Seung Won Lee M.D., Ph.D. ^{3 †}, Yong Joon Kim M.D., Ph.D. ^{1 †}

¹Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University, Seoul, Republic of Korea
²Department of Medical AI, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
³Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea

Co-corresponding author #2: Seung Won Lee, Yong Joon Kim
^#J. S. Lee and S. Kim equally contributed to this work as co-first authors
^†S. W. Lee and Y. J. Kim equally contributed to this work as co-corresponding authors

Abstract

Objective
To identify the risk of depression in individuals exposed to persistent blue light deprivation through blue light-filtering (BLF) intraocular lens (IOL), based on previous studies that have found that blue light is known to promote affective arousal and modulate emotional responses.

Design
A population-based cohort analysis.
Participants
Individuals who underwent cataract removal and IOL implantation in both eyes within one year between January 2012 and December 2018.

Methods
Participants were categorized into either clear IOL and BLF IOL. The National Health Insurance Sharing Service of South Korea database was queried for new diagnosis of depressive disorders. The full observation period spanned from January 1, 2008 to December 31, 2022.
Main outcome measures Incidence rates and hazard ratios were calculated for depressive disorders in individuals with BLF IOL and clear IOL using Cox proportional hazards model. Outcomes were adjusted for demographics, income and comorbidities.

Results
A total of 14,010 individuals (35.5% males, 71.4±9.20 years) who underwent BLF IOL implantations in both eyes within one year between 2012 and 2018 were age- and sex-matched to 14,010 individuals with clear IOL in both eyes. The incidence rate of depressive disorders was 27.8 per 1000 person-years for BLF IOL group in comparison to 24.1 per 1000 person-years for clear IOL group. The risk of depressive disorders was increased by 1.16 folds (95% confidence interval [CI] 1.09-1.23; P<0.001) among individuals with BLF IOL relative to those with clear IOL after adjusting for systemic comorbidities and follow-up duration. The risk for depressive disorders was especially high for individuals with BLF IOL between the ages of 50 and 64 (hazard ratio [HR] 1.30, 95% CI 1.14-1.48; P<0.001) and females (HR 1.17, 95% CI 1.09-1.25, P<0.001). Similar trends were observed in the sensitivity analysis and unmatched cohort analysis.

Conclusions
The risk for depressive disorders increases for individuals with BLF IOL relative to those with clear IOL. Long-term, persistent blue light deprivation may increase risks of depression, and particular age cohort and sex may be more vulnerable to the light deprivation than others.

논문정보