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단국대학교, 현 Mayo Clinic

Acta Biomater., Jul 24 2025, S1742-7061(25)00551-3 | https://doi.org/10.1016/j.actbio.2025.07.053 Low modulus PMMA-based bone cement for the reduction of adjacent vertebral fractures after vertebroplasty

Min Ji Kim ^{a †}, Shin Young Park ^{a †}, Sungwook Kang ^b, Ye Ji Lee^c, Sung-Jae Lee ^c, Jung Tae Kim^d, Sang Yoon Song ^e, Dong-Hee Kim^{e *}, Se Heang Oh ^{a f *}

^aDepartment of Nanobiomedical Science, Dankook University, Cheonan 31116, South Korea
^bDepartment of Smart Ocean Mobility Engineering, Changwon National University, Changwon 51140, South Korea
^cDepartment of Biomedical Engineering, College of Biomedical Science&Engineering, Inje University, Gimhae 50834, South Korea
^dResearch Center for Endocrine and Metabolic Diseases, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 65015, South Korea
^eDepartment of Orthopaedic Surgery, School of Medicine, Gyeongsang National University, Jinju 52727, South Korea
^fDepartment of Biomedical Sciences & Biosystems, Dankook University, Cheonan 31116, South Korea

^†These authors contributed equally
^*Corresponding authors: correspondence to Dong-Hee Kim or Se Heang Oh

Abstract

Vertebral augmentation employing polymethylmethacrylate (PMMA) bone cement is a widely used therapeutic technique for treating vertebral compression fractures. In this study, polydimethylsiloxane (PDMS)-enhanced PMMA bone cement (PDMS/PMMA) was developed to address the significant limitations associated with traditional PMMA bone cements in vertebroplasty: excessive exothermicity causing necrosis of normal bone tissues and high stiffness leading to fractures in adjacent vertebrae. The incorporation of PDMS into the PMMA bone cement results in consumption of the heat generated during polymerization, which prevents necrosis of surrounding tissue and speeds up the curing process of PDMS, showcasing the synergistic effects between PMMA and PDMS. The PDMS uniformly dispersed in the PMMA bone cement does not significantly alter the radiographic contrast of the cement. The ex vivo experiments conducted using osteoporotic porcine vertebrae demonstrated that vertebrae injected with low modulus PDMS/PMMA(10/90) exhibited a significant delay in adjacent bone fracture compared to those treated with PMMA alone. This study proposes that low modulus PMMA-based bone cement may serve as an advanced therapeutic material for vertebroplasty. STATEMENT OF SIGNIFICANCE: Vertebroplasty using PMMA bone cement often leads to secondary adjacent vertebral fractures due to its high stiffness and exothermic curing, which can damage surrounding bone tissue. In this study, we developed a PDMS-containing PMMA bone cement that significantly reduces curing temperature and stiffness while maintaining biocompatibility and radiopacity. The synergistic interaction between PDMS and PMMA helps minimize thermal necrosis and reduces the risk of adjacent vertebral fractures. Ex vivo tests using osteoporotic porcine vertebrae demonstrated that the low-modulus PDMS-containing PMMA bone cement significantly delayed adjacent fractures compared to conventional PMMA bone cement. This work presents a strategy to overcome long-standing complications of vertebroplasty and may contribute to safer and more effective treatment options for osteoporotic vertebral compression fractures.

논문정보

형식Research article
게재일2025년 07월 (BRIC 등록일 2025-08-01)
연구진국내 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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