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한빛사논문
- 조회323
University of California, San Francisco
Nat. Neurosci., Jul 14 2025, | https://doi.org/10.1038/s41593-025-01987-2
An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains
JaeYeon Kim1,2,22, Aunoy Poddar1,3,4,22, Kadellyn Sandoval1,5, Julia Chu1, Emma Horton1,4, Di Cui6, Keira Nakamura1, I-Ling Lu2,7, Michael Mui 1, Theresa Bartels 8,9, Christian M. Wood 10,11, Susana I. Ramos 12,13, David H. Rowitch2,8,9,14, Nadejda M. Tsankova12,13, Hosung Kim15, Chet C. Sherwood16, Boris W. Kramer17, Angela C. Roberts10,11, Pablo J. Ross18, Duan Xu6, Nicola J. Robertson19,20, Elizabeth A. Maga18, Peng Ji 21 & Mercedes F. Paredes1,2,3,5
1Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
2Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
3Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.
4Developmental and Stem Cell Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
5Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
6Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
7Department of Neonatology, University of California, San Francisco, San Francisco, CA, USA.
8Department of Paediatrics, University of Cambridge, Cambridge, UK.
9Wellcome–MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
10Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
11Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
12Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
13Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
14Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
15Department of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
16Department of Anthropology Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.
17Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
18Department of Animal Science, University of California, Davis, Davis, CA, USA.
19Institute for Women’s Health, University College London, London, UK.
20Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
21Department of Nutrition, University of California, Davis, Davis, CA, USA.
22These authors contributed equally: JaeYeon Kim, Aunoy Poddar.
1Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
2Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
3Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.
4Developmental and Stem Cell Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
5Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
6Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
7Department of Neonatology, University of California, San Francisco, San Francisco, CA, USA.
8Department of Paediatrics, University of Cambridge, Cambridge, UK.
9Wellcome–MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
10Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
11Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
12Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
13Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
14Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
15Department of Neurology, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
16Department of Anthropology Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC, USA.
17Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
18Department of Animal Science, University of California, Davis, Davis, CA, USA.
19Institute for Women’s Health, University College London, London, UK.
20Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
21Department of Nutrition, University of California, Davis, Davis, CA, USA.
22These authors contributed equally: JaeYeon Kim, Aunoy Poddar.
Corresponding author
Correspondence to Mercedes F. Paredes.
Abstract
Cortical GABAergic interneurons generated in the ventral developing brain travel long distances to their final destinations. While there are examples of interneuron migration in the neonatal human brain, the extent of postnatal migration across species and how it contributes to cortical interneuron composition remains unknown. Here we demonstrate that neonatal gyrencephalic brains, including humans, nonhuman primates and piglets, harbor an elaborate subventricular zone, termed the Arc, due to its curved morphology and expanded neuroblast populations. The Arc is absent in lissencephalic marmoset and mouse brains. Transcriptomic and histological approaches revealed that Arc neurons are diverse interneurons from the medial and caudal ganglionic eminences that migrate into the frontal, cingulate and temporal cortex. Arc-cortical targets exhibit an increase in VIP+ neuronal density compared to other regions. Our findings reveal that the Arc is a developmental structure that supports the expansion of postnatal neuronal migration for cortical interneuron patterning in gyrencephalic brains.
논문정보
- Research article
- 2025년 07월 (BRIC 등록일 2025-07-23)
- 국외 연구진
- 생명과학 > 신경생물학
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