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임호섭Hosub Lim
Brigham and Women’s Hospital, 한국기계연구원
Trends Biotechnol., Jul 02 2025, S0167-7799(25)00221-5 | https://doi.org/10.1016/j.tibtech.2025.06.006
Understanding the impact of antenatal corticosteroids via placenta and fetal lung microphysiological analysis platform (MAP) on a chip
Hosub Lim 1,2,9, Subin Yu 1,3,4,5,9, Hyo Jin Lee 4, Sang Mee Hwang 6, Dong Ha Kim 3, Jee Yoon Park 1,4, Luke P. Lee 1,3,7,8
1Harvard Institute of Medicine, Harvard Medical School, Harvard University, Brigham and Women’s Hospital, Boston, MA 02215, USA
2Department of Bionic Machinery, Institute of AI Robot, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea
3Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea
4Department of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seoul National University College of Medicine, Republic of Korea
5Institute of Reproductive Medicine and Population, Medical Research Center at Seoul National University, Seoul, Republic of Korea
6Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
7Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA
8Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea
9These authors contributed equally to this work.
Correspondence: Jee Yoon Park, Luke P. Lee
1Harvard Institute of Medicine, Harvard Medical School, Harvard University, Brigham and Women’s Hospital, Boston, MA 02215, USA
2Department of Bionic Machinery, Institute of AI Robot, Korea Institute of Machinery and Materials, Daejeon 34103, Republic of Korea
3Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea
4Department of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seoul National University College of Medicine, Republic of Korea
5Institute of Reproductive Medicine and Population, Medical Research Center at Seoul National University, Seoul, Republic of Korea
6Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
7Department of Bioengineering, Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA
8Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Republic of Korea
9These authors contributed equally to this work.
Correspondence: Jee Yoon Park, Luke P. Lee
Abstract
Antenatal corticosteroids are recommended for preterm births to enhance lung maturity; however, the guidelines are based on limited studies. Here, we present a placenta-fetal lung microphysiological analysis platform (MAP) to study how corticosteroids promote fetal lung maturation and determine their optimal concentration with minimal side effects. We create trophoblast-capillary-pneumocyte MAP on chips to analyze the transport of corticosteroids from mother to fetus through the placenta. We assessed surfactant production from the pneumocyte after exposure to different concentrations, types, and durations of corticosteroids in the trophoblast layer. We found the concentrations of corticosteroids over 5 mM reduced trophoblast viability and did not increase the surfactant production from pneumocytes. Our research on placenta-fetal lung MAP provides insight into how corticosteroids improve the production of surfactant from immature pneumocytes as they transition from the placenta and suggests that determining the appropriate dosage of corticosteroids to maximize effectiveness while preventing damage to trophoblasts is crucial.
논문정보
- Research article
- 2025년 07월 (BRIC 등록일 2025-07-05)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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