한빛사
>
한빛사논문
한빛사논문
- 조회105
Alzheimers. Dement., Jul 2025, 21 (7) | https://doi.org/10.1002/alz.70443
Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance
Na-Yeon Jung1, SeungWook Kim2, Joon-Kyung Seong3, Duk L. Na4, Sang Won Seo4, Jihwan Yun5, Eun Hye Lee4, Daeun Shin4, Heeyoung Kang6, Sung Hoon Kang7, Kyung Won Park8,†, Geon Ha Kim9, Jee Hyang Jeong10, Hee Jin Kim4, Sun Min Lee11, Hyemin Jang12, So Young Moon11, Eun-Joo Kim13 and the Longitudinal Study of Early Onset Dementia and Family Members(LEAF) Investigators
1Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea
2Department of Bio-convergence Engineering, Korea University, Seoul, Republic of Korea
3School of Biomedical Engineering, Korea University, Seoul, Republic of Korea
4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
5Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea
6Department of Neurology, Gyeongsang National University Hospital, College of Medicine, Jinju, Republic of Korea
7Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea
8Department of Neurology, Dong-A Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea
9Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea
10Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea
11Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea
12Department of Neurology, Asan Medical Center, Seoul, Republic of Korea
13Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic ofKoreaCorrespondenceSeungWook Kim
SeungWook Kim, So Young Moon, and Eun-Joo Kim contributed equally to this study.
1Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea
2Department of Bio-convergence Engineering, Korea University, Seoul, Republic of Korea
3School of Biomedical Engineering, Korea University, Seoul, Republic of Korea
4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
5Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea
6Department of Neurology, Gyeongsang National University Hospital, College of Medicine, Jinju, Republic of Korea
7Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea
8Department of Neurology, Dong-A Medical Center, Dong-A University College of Medicine, Busan, Republic of Korea
9Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea
10Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea
11Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea
12Department of Neurology, Asan Medical Center, Seoul, Republic of Korea
13Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Republic ofKoreaCorrespondenceSeungWook Kim
SeungWook Kim, So Young Moon, and Eun-Joo Kim contributed equally to this study.
†Dr. Kyung Won Park is deceased.
Correspondence : SeungWook Kim, So Young Moon, and Eun-Joo Kim
Correspondence : SeungWook Kim, So Young Moon, and Eun-Joo Kim
Abstract
Frontotemporal dementia (FTD) with right anterior temporal lobe (rATL) predominance lacks universally agreed-upon diagnostic criteria. This study validated the Amsterdam diagnostic tree (ADT) for right temporal variant FTD (rtvFTD) and the diagnostic criteria for semantic behavioral variant FTD (sbvFTD), examining clinical, behavioral, and imaging differences.
The study included 138 patients with behavioral variant FTD and 87 with semantic variant primary progressive aphasia who had 3D T1-weighted magnetic resonance imaging scans. The participants were grouped into rtvFTD and sbvFTD by respective imaging criteria.
We identified 42 rtvFTD and 20 sbvFTD patients. ADT showed 81% sensitivity and 29% specificity, whereas sbvFTD criteria had 45% sensitivity and 55% specificity.
The unfavorable validation of both diagnostic criteria in Korean FTD patients may result from socio-cultural differences, the lack of standardized tools for assessing abnormal behaviors, and the retrospective nature of the study. The perspectives on rATL also differed between the two studies.
Frontotemporal dementia (FTD) with right anterior temporal lobe (rATL) predominance is a controversial FTD syndrome, also referred to as right temporal variant FTD (rtvFTD), or right predominant semantic variant primary progressive aphasia. Two clinical criteria for rATL have been proposed: One is the Amsterdam diagnostic tree for rtvFTD and the other is for semantic behavioral variant FTD (sbvFTD). Our validation study suggested the need for standardized tools and highlighted theoretical distinctions between rtvFTD and sbvFTD.
논문정보
- Research article
- 2025년 07월 (BRIC 등록일 2025-07-04)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
관련분야 논문보기
