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Small Methods, Jun 29 2025, | https://doi.org/10.1002/smtd.202500617
Comprehensive Osteosarcoma Treatment with Multifunctional Composite Hydrogels Enabling Combined Photothermal Cancer Ablation and Osteoinductive Tissue Regeneration
Hayeon Byun 1, Taeyeon Hwang 1, Hyoryong Lee 2, Yun-Jung Choi 3, Dong-Jae Kim 3, Eunji Park 1, Eunhyung Kim 1, Sukho Park 2, Heungsoo Shin 1,4
1Department of Bioengineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
2Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology, 333 Techno Jungang Daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
3Laboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science and Technology, 333 Techno Jungang Daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
4Institute of Nano Science and Technology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
H. B., T. H., and H. L. contributed equally to this work.
Corresponding Authors: Sukho Park, Heungsoo Shin
1Department of Bioengineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
2Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology, 333 Techno Jungang Daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
3Laboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science and Technology, 333 Techno Jungang Daero, Hyeonpung-eup, Dalseong-gun, Daegu, 42988, Republic of Korea.
4Institute of Nano Science and Technology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
H. B., T. H., and H. L. contributed equally to this work.
Corresponding Authors: Sukho Park, Heungsoo Shin
Abstract
Osteosarcoma treatment can lead to considerable loss of bone tissue, creating a challenging microenvironment for recovery. Here, a novel biomaterial is described for tumor treatment via photothermal therapy and bone-tissue regeneration. Multifunctional composite hydrogels can be fabricated by incorporating mineralized magnetic fibers (G-mMFs) into a gelatin-genipin hydrogel. The G-mMFs exhibit notable temperature increases in response to near-infrared irradiation, and superior disruption of tumor tissue follows hyperthermia therapy in a tumor-bearing mouse model. G-mMFs protect stem cells from the oxidative stress anticipated after tumor ablation, following significant increases in catalase and anti-apoptotic gene expression. G-mMFs demonstrate enhanced osteoinductivity, with nearly 90% of human adipose-derived stem cells exhibiting osteogenic markers. Adenosine signaling-mediated osteogenesis and restoration of osteogenesis under oxidative stress can be demonstrated through stem-cell differentiation in the presence of H2O2. In vivo, regeneration of bone tissue can be assessed using a calvarial bone-defect mouse model, with nearly twice the amount of bone formation in the G-mMF group compared with mice without implantation, along with a more mature bone-tissue structure. Collectively, these study results present G-mMFs as a multifunctional biomaterial that simultaneously addresses tumor ablation and bone regeneration, offering a promising strategy for the comprehensive treatment of osteosarcoma.
논문정보
- Research article
- 2025년 06월 (BRIC 등록일 2025-07-03)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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