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한빛사논문
한빛사논문
- 조회62
New Phytol., Jun 18 2025, | https://doi.org/10.1111/nph.70308
Old player, new roles: defining the role of the plastidial phosphorylase
David Seung1, Slawomir Orzechowski2 and Joerg Fettke3
1John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK;
2Biochemistry and Microbiology, Institute of Biology, SGGW, 159 Nowoursynowska Street, Warsaw, 02-776, Poland;
3Biopolymer Analytics, Institute of Biology and Biochemistry, University of Potsdam, Karl-Liebknechtstr. 24/25, Potsdam, 14476, Germany
Author for correspondence: Joerg Fettke
1John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK;
2Biochemistry and Microbiology, Institute of Biology, SGGW, 159 Nowoursynowska Street, Warsaw, 02-776, Poland;
3Biopolymer Analytics, Institute of Biology and Biochemistry, University of Potsdam, Karl-Liebknechtstr. 24/25, Potsdam, 14476, Germany
Author for correspondence: Joerg Fettke
Abstract
The plastidial phosphorylase (Pho1 or Phs1; E.C. 2.4.1.1) is a ubiquitous enzyme among plants that catalyzes the formation and degradation of glucans. Although the first report connecting Pho1 with starch metabolism came out > 80 years ago, its precise role is still a matter of debate. In this article, we evaluate the catalytic and regulatory mechanisms of Pho1 in the context of known mechanisms in its animal, fungal, and bacteria homologs. We further discuss recent breakthroughs in understanding Pho1's function in initiating starch granule formation. This role is relevant to both photosynthetic and nonphotosynthetic tissues, as loss of Pho1 affects the regulation of the number of transitory starch granules in Arabidopsis leaves under various metabolic contexts, as well as the number of storage starch granules and/or starch granule morphology in wheat endosperm and potato tubers. Our comparison of phosphorylases across kingdoms reveals several regulatory mechanisms that require further investigation in plants. We also discuss emerging research on Pho1 protein interactions that give rise to other metabolic processes, such as photosynthesis. Overall, these multiple emerging roles of phosphorylase emphasize its importance in plant metabolism and its broad potential as a target for crop improvement.
논문정보
- Review Paper
- 2025년 06월 (BRIC 등록일 2025-07-04)
- 국외 연구진
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