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Science, Jun 19 2025, 388 (6753) | https://doi.org/10.1126/science.adm8203
Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep
Sang Soo Lee 1, Qiang Liu 1, Alexandra H. R. Cheng 2, Dong Won Kim 3, Daphne M. Boudreau 1, Anuradha Mehta 1, Mehmet F Keles 1, Rafal Fejfer 3, Isabelle Palmer 1, Kristen H. Park 1, Heike Münzberg 4, Timothy D. Harris 2 5, Austin R. Graves 2 6, Seth Blackshaw 3 6, Mark N. Wu 1 3 *
1Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
3Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, MD, USA.
4Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
5Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
6Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
3Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, MD, USA.
4Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
5Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
6Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
*Corresponding author: correspondence to Mark N. Wu
Abstract
Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of thalamic nucleus reuniens (RE) neurons activated during sleep deprivation (SD) and required for sleep homeostasis. Optogenetic activation of RE neurons leads to an unusual phenotype: presleep behaviors (grooming and nest organizing) followed by prolonged, intense sleep that resembles RS. Inhibiting RE activity during SD impairs subsequent RS, which suggests that these neurons signal sleep need. RE neurons act upstream of sleep-promoting zona incerta cells, and SD triggers plasticity of this circuit to strengthen their connectivity. These findings reveal a circuit mechanism by which sleep need transforms the functional coupling of a sleep circuit to promote persistent, deep sleep.
논문정보
- Research article
- 2025년 06월 (BRIC 등록일 2025-06-23)
- 국외 연구진
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