김성욱 (숙명여자대학교) | 한빛사논문 > 한빛사

한빛사논문

조회345

숙명여자대학교

J. Control. Release, Jun 10 2025, S0168-3659(25)00566-8 | https://doi.org/10.1016/j.jconrel.2025.113946 Novel biomarker discovery-coupled plasma therapy with enhanced tumor penetration for non-surgical treatment of cervical cancer

Sung Wook Kim ^a,1, Min-Jung Kang ^c,1, Young Sun Kim^d,1, Woo Yeon Hwang ^d,1, Aram Lee ^a,b, Quoc-Viet Le ^e, Ihn Han^f, Min Hyung Jung ^d, Kiyong Na ^g, Kyung Sook Kim ^h, Sung Jong Lee ⁱ, Dong Soo Suh ^j, Ki Hyung Kim ^j, Kyung Un Choi^k, Eun Ha Choi ^f, Gayong Shim ^l, Jongmin Kim ^a,b, Byung Su Kwon ^d

^aDivision of Biological Sciences, Sookmyung Women's University, Seoul 04310, South Korea
^bResearch Institute for Women's Health, Sookmyung Women's University, Seoul 04310, South Korea
^cDepartment of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea
^dDepartment of Obstetrics & Gynecology, College of Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul 02447, South Korea
^eFaculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam
^fPlasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
^gDepartment of Pathology, School of Medicine, Kyung Hee Medical Center, Kyung Hee University, Seoul 02447, South Korea
^hDepartment of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 02447, South Korea
ⁱDepartment of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
^jDepartments of Obstetrics and Gynecology, Medical Research Institute, Pusan National University School of Medicine, Busan, South Korea
^kDepartment of Pathology, Medical Research Institute, Pusan National University School of Medicine, Busan, South Korea
^lSchool of Systems Biomedical Science and Integrative Institute of Basic Sciences, Soongsil University, Seoul 06978, Republic of Korea

¹These authors contributed equally to this study.
Corresponding authors : Eun Ha Choi, Gayong Shim, Jongmin Kim, Byung Su Kwon

Abstract

There is a growing need for non-surgical, fertility-preserving treatments for young patients with cervical cancer. This study explores biomarker-driven non-thermal plasma (NTP) therapy as a localized therapeutic strategy with deep tissue penetration, highlighting its potential for controlled oxidative modulation and targeted drug delivery. Screening of ROS-related molecules revealed an association between sensitivity to NTP and the expression of the antioxidant enzyme superoxide dismutase 1 (SOD1), with human papillomavirus (HPV) oncoprotein E6 and p53 identified as upstream regulators. Additionally, NTP was shown to influence toll-like receptor signaling 9 and induce immunogenic cell death (ICD), enhancing localized immune activation within the tumor microenvironment. In a xenografted animal tumor model, SOD1 was identified as a potential biomarker for NTP, while in a syngeneic tumor model using TC-1 cell lines expressing HPV16-E6 and HPV16-E7, NTP treatment demonstrated both antitumor effects and an increase in tumor-infiltrating lymphocytes. Evaluation of NTP penetration in patient uterine tissues showed that the depth of penetration was significantly greater in the transformation zone, where cervical cancer occurs, than in the squamous zone. Notably, NTP reached a penetration depth of ~5 mm in cervical cancer tissues, suggesting its potential as a drug delivery enhancer for localized therapeutic applications. These findings suggest that NTP may serve as a novel non-invasive platform for controlled therapeutic delivery in cervical cancer treatment, offering an alternative to conventional surgical approaches.

논문정보

형식Research article
게재일2025년 06월 (BRIC 등록일 2025-06-13)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 다학제 융합/복합

댓글 작성 로그인

CV 열람하기

연락처 보기