이기범 (Rutgers, The State University of New Jersey) | 한빛사논문 > 한빛사

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Rutgers, The State University of New Jersey

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Adv. Funct. Mater., 11 June 2025 | https://doi.org/10.1002/adfm.202508435 Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Wei Xu^1,2, Fenghui Wang³, Joshua Stein², Siqiao Wang¹, Pengfei Jiang³, Letao Yang^1,3, Liming Cheng¹, Ki-Bum Lee²

¹Division of Spine, Department of Orthopaedics, Shanghai Tongji Hospital, Tongji University School of Medicine, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji University, Shanghai, 200092 China
²Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, 08854 USA
³Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092 China

Corresponding Authors: Letao Yang, Liming Cheng, Ki-Bum Lee

Abstract

Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms, including ischemia, oxidative stress, and neuroinflammation. These pathological processes lead to neuronal apoptosis and create a microenvironment that hinders neural regeneration. Recent advancements in tissue engineering have introduced biomaterials that feature precisely engineered micro- and nanoscale topographical cues, representing a novel class of therapeutic interventions. These biomimetic scaffolds are designed to modulate the mechanotransduction pathways of neural stem cells (NSCs), thereby enhancing neurogenesis and guiding neuronal differentiation. They also influence essential cellular processes such as adhesion, cytoskeletal alignment, morphological polarization, and gene regulation. This review systematically evaluates current strategies for optimizing topographical designs, emphasizing their role in promoting neurite outgrowth, axonal guidance, and synaptic reformation. The mechanisms are elucidated by which scaffold topographies regulate NSC fate decisions through mechanobiological signaling and interactions with the extracellular matrix. Additionally, critical barriers are analyzed for clinical translation, including the precision fabrication of tunable architectures, the scalability of novel materials, and strategies to mitigate glial scar formation. By synthesizing interdisciplinary insights from biomaterial science, neurobiology, and translational medicine, this work aims to provide a roadmap for developing next-generation topographical scaffolds that address the pressing clinical need for effective SCI repair.

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형식Review Paper
게재일2025년 06월 (BRIC 등록일 2025-06-13)
연구진국외 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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