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ACS Nano, Jun 05 2025, | https://doi.org/10.1021/acsnano.4c16277
Diffusion of DNA on Atomically Flat 2D Material Surfaces
Dong Hoon Shin 1,2,3, Sung Hyun Kim 1,4,5, Kush Coshic 6, Kenji Watanabe 7, Takashi Taniguchi 7, Gerard J Verbiest 2, Sabina Caneva 2, Aleksei Aksimentiev 6,8, Peter G. Steeneken 1,2, Chirlmin Joo 1,9
1Kavli Institute of Nanoscience Delft, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
2Department of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
3Department of Electronics and Information Engineering, Korea University, Sejong 30019, Republic of Korea.
4Department of Bionanoscience, Delft University of Technology, 2629 HZ Delft, The Netherlands.
5New and Renewable Energy Research Center, Ewha Womans University, Seoul 03760, Republic of Korea.
6Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
7Advanced Materials Laboratory, National Institute for Materials Science, Tsukuba 305-0044, Japan.
8Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
9Department of Physics, Ewha Womans University, Seoul 03760, Republic of Korea.
D.H.S. and S.H.K. contributed equally to this work.
Corresponding Authors : Peter G. Steeneken, Chirlmin Joo
1Kavli Institute of Nanoscience Delft, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
2Department of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
3Department of Electronics and Information Engineering, Korea University, Sejong 30019, Republic of Korea.
4Department of Bionanoscience, Delft University of Technology, 2629 HZ Delft, The Netherlands.
5New and Renewable Energy Research Center, Ewha Womans University, Seoul 03760, Republic of Korea.
6Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
7Advanced Materials Laboratory, National Institute for Materials Science, Tsukuba 305-0044, Japan.
8Department of Physics and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
9Department of Physics, Ewha Womans University, Seoul 03760, Republic of Korea.
D.H.S. and S.H.K. contributed equally to this work.
Corresponding Authors : Peter G. Steeneken, Chirlmin Joo
Abstract
Accurate localization and delivery of biomolecules are pivotal for building tools to understand biology. The interactions of biomolecules with atomically flat 2D surfaces offer a means to realize both the localization and delivery, yet experimental utilization of such interactions has remained elusive. By combining single-molecule detection methods with computational approaches, we comprehensively characterize the interactions of individual DNA molecules with hexagonal boron nitride (hBN) surfaces. Our experiments directly show that, upon binding to a hBN surface, a DNA molecule retains its ability to diffuse along the surface. Further, we show that the magnitude and direction of such diffusion can be controlled by the DNA length, the surface topography, and atomic defects. We observe that the diffusion speed of the biomolecules is significantly lower than indicated by molecular dynamic simulations. Through computational analysis, we present the model based on temporary trapping by atomic defects that accounts for those observations. By fabricating a narrow hBN ribbon structure, we achieve pseudo-1D confinement, demonstrating its potential for nanofluidic guiding of biomolecules.
논문정보
- Research article
- 2025년 06월 (BRIC 등록일 2025-06-11)
- 국내(교신)+국외 연구진
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