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- 조회108
Clin. Microbiol. Infect., Available online 7 June 2025 | https://doi.org/10.1016/j.cmi.2025.06.002
Species-specific risk of ophthalmic involvement in candidemia: a propensity-matched competing risk analysis
Sung-Woon Kang 1,2 #, SolAh Han 3 #, Geonui Kim 2,4, Hyo-Ju Son 5, Eun Jeong Won 6, Heungsup Sung 6, Mi-Na Kim 6, Euijin Chang 2, Seongman Bae 2, Jiwon Jung 2, Min Jae Kim 2, Sung-Han Kim 2, Sang-Oh Lee 2, Sang-Ho Choi 2, Yang Soo Kim 2, Joo Yong Lee 3, Yong Pil Chong 2
1Department of Infection Control, Armed Forces Daejeon Hospital, Daejeon, Republic of Korea
2Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
4Department of Infectious Diseases, Kyunghee University Hospital, Seoul, Republic of Korea
5Uijeongbu Eulji Medical Center, University of Eulji College of Medicine, Uijeongbu, Gyeongggi-do, Republic of Korea
6Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
#These authors contributed equally to this work.
Corresponding author : Yong Pil Chong
1Department of Infection Control, Armed Forces Daejeon Hospital, Daejeon, Republic of Korea
2Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
4Department of Infectious Diseases, Kyunghee University Hospital, Seoul, Republic of Korea
5Uijeongbu Eulji Medical Center, University of Eulji College of Medicine, Uijeongbu, Gyeongggi-do, Republic of Korea
6Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
#These authors contributed equally to this work.
Corresponding author : Yong Pil Chong
Abstract
Objectives
Given the limited data on species-specific ocular involvement in candidemia, we aimed to assess the differential risk of ocular involvement according to Candida species in patients with candidemia.
Given the limited data on species-specific ocular involvement in candidemia, we aimed to assess the differential risk of ocular involvement according to Candida species in patients with candidemia.
Methods
A retrospective review was conducted of candidemia patients who underwent funduscopic examination at a tertiary center in Seoul, Korea between January 2014 and December 2023. Ocular involvement, defined as endophthalmitis, was determined by two retinal specialists. Propensity score matching and competing risk analyses were performed to adjust for pre-specified risk factors and mitigate competing-risk bias.
Results
A total of 674 candidemia patients were included. Endophthalmitis was identified in 5% (32/674), and probable chorioretinitis in 10% (67/674). The prevalence of endophthalmitis was relatively high in Candida albicans (16/245, 7%) and Candida tropicalis (13/126, 10%), but low in Candida glabrata (0/193), Candida parapsilosis (2/68, 3%), and Candida krusei (0/19). Competing risk analysis identified C. albicans or C. tropicalis infection (subdistribution hazard ratio [sHR] 7.90, 95% confidence interval [CI] 2.42–25.75) as an independent risk factor for endophthalmitis. In propensity score-matched analyses, C. albicans (sHR 5.85, 95% CI 1.71–19.95) and C. tropicalis (sHR 6.97, 95% CI 1.58–29.85) were each significantly more associated with ocular involvement than non-albicans and non-tropicalis species.
Conclusion
While ophthalmic examinations are already recommended in all candidemia cases, our findings underscore their particular importance in C. albicans and C. tropicalis infections, where ocular involvement is significantly more common than in those involving other Candida species.
논문정보
- Research article
- 2025년 06월 (BRIC 등록일 2025-06-09)
- 국내 연구진
- 의약학 > 감염의학
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