한빛사
>
한빛사논문
한빛사논문
- 조회124
Sci. Adv., Jun 06 2025, 11 (23) eadt4831 | https://doi.org/10.1126/sciadv.adt4831
Machine reading and recovery of colors for hemoglobin-related bioassays and bioimaging
Sang Mok Park 1, Semin Kwon 1, Yuhyun Ji 1, Haripriya Sakthivel 1, Jung Woo Leem 1, Yunsang Kwak 2, Jonathan Huang 1 3, George T-C Chiu 4, Andrew R O'Brien 3 5, Raymond L Konger 5 6 7 8, Ying Wang 3 9, Young L. Kim 1 8 10 11 *
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
2Department of Mechanical System Engineering, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi-si, Gyeongsangbuk-do 39177, Republic of Korea.
3Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
4School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
5Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA.
6Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
7Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
8Richard L. Roudebush Veterans' Administration Medical Center, Indianapolis, IN 46202, USA.
9Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
10Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.
11Purdue Quantum Science and Engineering Institute, West Lafayette, IN 47907, USA.
2Department of Mechanical System Engineering, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi-si, Gyeongsangbuk-do 39177, Republic of Korea.
3Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
4School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
5Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA.
6Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
7Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
8Richard L. Roudebush Veterans' Administration Medical Center, Indianapolis, IN 46202, USA.
9Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
10Purdue Institute for Cancer Research, West Lafayette, IN 47907, USA.
11Purdue Quantum Science and Engineering Institute, West Lafayette, IN 47907, USA.
*Corresponding author: correspondence to Young L. Kim
Abstract
Despite advances in machine learning and computer vision for biomedical imaging, machine reading and learning of colors remain underexplored. Color consistency in computer vision, color constancy in human perception, and color accuracy in biomedical imaging are intertwined, complicating digital color-based diagnostics. Existing color reference charts and correction algorithms are inadequate for mobile health (mHealth) and telemedicine in digital health applications where detecting subtle color changes is critical. We present a machine reading and learning platform for color recognition and quantification to extract diagnostic information from colors. A unique combination of spectroscopic gamut determination, reference color optimization, nonsubjective quantification metrics, and neural network-based color recovery retrieves absolute colors of biological tissue. Studies on inflammation bioimaging of photocarcinogenesis and mHealth blood hemoglobin assessment demonstrate accuracy and precision in color recovery across diverse acquisition scenarios. The reported framework overcomes limitations of conventional colorimetric detection, enabling machine-compatible color-based bioassays and bioimaging, advancing digital diagnostics.
논문정보
- Research article
- 2025년 06월 (BRIC 등록일 2025-06-09)
- 국내+국외 연구진
- 바이오·의료융합 > 다학제 융합/복합
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
