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Coord. Chem. Rev., Available online 4 June 2025 | https://doi.org/10.1016/j.ccr.2025.216848
Inorganic nanoparticle-based cancer immunotheranostics
Seohee Lee a,1, Jihye Lee a,1, Mihyeon Park a, Jieun Kim a, Huiguk Byun b, Jihoon Kim c, Won Jong Kim a,d
aDepartment of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
bDepartment of Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
cSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea
dOmniaMed Co, Ltd., Pohang 37673, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors: Jihoon Kim, Won Jong Kim
aDepartment of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
bDepartment of Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea
cSchool of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea
dOmniaMed Co, Ltd., Pohang 37673, Republic of Korea
1These authors contributed equally to this work.
Corresponding authors: Jihoon Kim, Won Jong Kim
Abstract
Inorganic nanoparticle (NP)-based immunotheranostics, which integrate diagnostic imaging with therapeutic interventions and immunomodulation, have emerged as a powerful strategy in cancer treatment. This review highlights recent advances in the design of multifunctional inorganic and hybrid nanoplatforms, including Au-, Mn-, iron oxide-, mesoporous silica-, and C-based systems, metal–organic frameworks, and quantum dots, that co-deliver chemotherapeutic agents, immune checkpoint inhibitors, and immunostimulatory molecules. Moreover, applications of these platforms in tracking metastatic dissemination and monitoring the populations of immune cells, including T cells, natural killer cells, and tumor-associated macrophages, are explored. By integrating emerging insights in nanotechnology with state-of-the-art immunotherapeutic strategies, this review highlights the evolving landscape of personalized cancer therapy. Furthermore, it underscores the translational potentials of immunotheranostic platforms in bridging diagnosis, treatment, and immunomodulation to achieve more effective, durable, and individualized clinical outcomes.
논문정보
- Review Paper
- 2025년 06월 (BRIC 등록일 2025-06-05)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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