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Adv. Healthc. Mater., May 27 2025, | https://doi.org/10.1002/adhm.202501058
MOF-Based Single-Atom and Metal Cluster Catalysts by Room-Temperature Synthesis for Tumor Therapy
Subin Yu 1,2, Haeun Kang 1, Seohyeon Jee 3, WooYeon Moon 3, Dohyub Jang 4,5, Wen-Tse Huang 6, Dongjun Kim 7, Kyungwha Chung 2,8, Dong-Il Won 1, Jungwon Park 7, Ru-Shi Liu 6, Kyungmin Choi 3, Sehoon Kim 5,9, Luke P. Lee 1,2,8,10,11, Dong Ha Kim 1,12,13,14,15
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
2Harvard Institute of Medicine, Harvard Medical School, Harvard University, Brigham and Women's Hospital, Boston, MA, 02115, USA.
3Department of Chemical and Biological Engineering, Sookmyung Women's University, Seoul, 04310, Republic of Korea.
4Department of Biomicrosystem Technology, Korea University, Seoul, 02841, Republic of Korea.
5Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
6Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
7School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
8Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, South Korea.
9KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, South Korea.
10Department of Bioengineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
11Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA.
12Basic Sciences Research Institute (Priority Research Institute), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
13Nanobio∙Energy Materials Center (National Research Facilities and Equipment Center), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
14College of Medicine, Ewha Womans University, 25, Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07804, Republic of Korea.
15Gradutate Program in Innovative Biomaterials Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
S.Y. and H.K. contributed equally to this work.
Corresponding Authors: Jungwon Park, Ru-Shi Liu, Kyungmin Choi, Sehoon Kim, Luke P. Lee, Dong Ha Kim
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
2Harvard Institute of Medicine, Harvard Medical School, Harvard University, Brigham and Women's Hospital, Boston, MA, 02115, USA.
3Department of Chemical and Biological Engineering, Sookmyung Women's University, Seoul, 04310, Republic of Korea.
4Department of Biomicrosystem Technology, Korea University, Seoul, 02841, Republic of Korea.
5Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.
6Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
7School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
8Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, South Korea.
9KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, South Korea.
10Department of Bioengineering, University of California, Berkeley, Berkeley, CA, 94720, USA.
11Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA.
12Basic Sciences Research Institute (Priority Research Institute), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
13Nanobio∙Energy Materials Center (National Research Facilities and Equipment Center), Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
14College of Medicine, Ewha Womans University, 25, Magokdong-ro 2-gil, Gangseo-gu, Seoul, 07804, Republic of Korea.
15Gradutate Program in Innovative Biomaterials Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea.
S.Y. and H.K. contributed equally to this work.
Corresponding Authors: Jungwon Park, Ru-Shi Liu, Kyungmin Choi, Sehoon Kim, Luke P. Lee, Dong Ha Kim
Abstract
Metal-organic frameworks (MOFs) are widely used as substrates for creating single-atom catalysts due to their abundance of ligands, facilitating enzyme-like activity for biomedical applications. However, the high-temperature calcination process for single-atom catalysts limits economical, efficient, and large-scale synthesis. Here, a simple room-temperature synthesis of MOF-based single-atom and metal cluster catalysts is presented for tumor therapy. Fe/MOF is obtained through a coordination reaction at room temperature, while Au/MOF is synthesized from Au3+/MOF by introducing a reducing agent. Au/MOF effectively generates hydrogen peroxide (H2O2) from glucose, outperforming Au3+/MOF, and Fe/MOF subsequently produced hydroxyl radicals (•OH) by decomposing the generated H2O2via accelerated peroxidase-like activity in an acidic environment. In vitro and in vivo studies confirm a significantly enhanced cancer eradication ability compared to the PBS-treated group by combining cascade enzymatic activity, destruction of oxidative homeostasis, and excessive mitochondrial-mediated lipid peroxidation. The novel synthesis process of MOF-based metal single-atom catalysts establishes a new paradigm for fabricating effective enzyme-like nanomaterials for multimodal tumor therapy.
논문정보
- Research article
- 2025년 05월 (BRIC 등록일 2025-05-28)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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