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인천대학교

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Ageing Res. Rev., May 21 2025, S1568-1637(25)00127-8 | https://doi.org/10.1016/j.arr.2025.102781 Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: a systematic review and meta-analysis

Joon Ho Lee ^a,b,c,♯, Jin-Sun Jun ^d, Nyeonju Kang^a,b,c, Ryul Kim^e, Beom Jin Choi^a,b,c, Kyeongho Byun ^a, Kiwon Park ^f, Jee-Young Lee ^e, Beomseok Jeon ^g

^aDivision of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, Korea
^bDepartment of Human Movement Science, Incheon National University, Incheon, Korea
^cNeuromechanical Rehabilitation Research Laboratory, Incheon National University, Incheon, Korea
^dDepartment of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
^eDepartment of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea
^fDepartment of Mechatronics Engineering, Incheon National University, Incheon, Korea
^gDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

^♯The first two authors contributed equally to this work.
Correspondence to: Nyeonju Kang, Ryul Kim

Abstract

Background
We aimed to compare the acute and retention effects of motor training alone versus its combination with transcranial direct current stimulation (tDCS) on motor symptoms in Parkinson’s disease (PD) patients.

Method
Two independent reviewers searched for randomized controlled trials that applied motor training with active tDCS versus sham tDCS with motor function as an outcome measure for patients with PD. Random-effects meta-analyses were conducted to calculate standardized mean differences between the effects of motor training with active tDCS versus sham tDCS on motor function. A total of 16 randomized controlled trials (344 PD patients) were eligible for meta-analysis, resulting in 75 motor function comparisons for data synthesis.

Results
Motor training with active tDCS showed positive acute effects on overall motor function compared to motor training with sham tDCS, particularly improving step length and gait speed. Moderator variable analyses indicated that these acute effects persisted regardless of the number of sessions or the targeted brain regions for tDCS. Meta-regression analysis showed that a higher proportion of female participants and shorter PD duration were associated with greater acute effects. However, no positive retention effects of motor training with active tDCS on overall motor function were observed.

Conclusions
Our results suggest that combining motor training with tDCS improves motor function, particularly in gait-related parameters, in PD patients. However, these effects were not sustained over time, highlighting the temporary nature of the benefits. Sex differences may influence the acute effects of combined motor training and tDCS interventions.

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형식Review Paper
게재일2025년 05월 (BRIC 등록일 2025-05-26)
연구진국내 연구진
분야 의약학 > 신경의학

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