진수빈 (성균관대학교, IBS) | 한빛사논문 > 한빛사

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조회209

성균관대학교, IBS

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Nat. Protoc., Published: 19 May 2025 | https://doi.org/10.1038/s41596-025-01184-2 An injectable conductive hydrogel for closed-loop and robot-assisted rehabilitation via stretchable patch-type electrodes

Subin Jin ^1,2,6, Heewon Choi ^2,3,6, Donghee Son^2,3,4,* & Mikyung Shin ^1,2,5,*

¹Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.
²Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
³Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
⁴Department of Artificial Intelligence System Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
⁵Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.

⁶These authors contributed equally: Subin Jin, Heewon Choi.

^*Corresponding authors: correspondence to Donghee Son or Mikyung Shin

Abstract

Conventional therapies for severe musculoskeletal and neurological injuries require lengthy recovery periods, which may result in residual disabilities. As an innovative rehabilitation approach, the combination of soft conducting hydrogels as an injectable tissue prosthesis with self-healing, stretchable bioelectronic devices offers a promising solution to expedite tissue repair and enhance functional restoration. This class of tissue prostheses can help address the critical limitations of traditional materials and devices by providing a minimally invasive approach to filling tissue defects and reconstructing the electrophysiological environment. The integration of an injectable tissue prosthesis with exoskeleton robotics in closed-loop systems enables tailored rehabilitation interventions that optimize motor function efficiency. Here we provide the step-by-step instructions for the development and characterization of injectable tissue-interfacing conductive hydrogels and soft self-healing, stretchable bioelectronic devices. We also describe how to establish a fully integrated closed-loop rehabilitation system and show its efficacy in a rat model of volumetric muscle loss. Using this approach, we have achieved accelerated tissue regeneration and improved myofiber regeneration in rats, underscoring the potential of this approach to improve rehabilitation strategies for severe injuries. The protocol is suitable for users with experience in biomaterials, devices and animal handling and requires 30 d to complete.

논문정보

형식Research article
게재일2025년 05월 (BRIC 등록일 2025-05-20)
연구진국내 연구진
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