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Signal Transduct. Target. Ther., 12 May 2025 | https://doi.org/10.1038/s41392-025-02234-7 Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline

Youngpyo Nam¹, Sehwan Kim¹, Jun-Yeong Lee¹, Jaekwang Kim² and Sang Ryong Kim¹

¹School of Life Science and Biotechnology, BK21 FOUR KNU Creative BioResearch Group, Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea and
²Dementia Research Group, Korea Brain Research Institute, Daegu, Republic of Korea

These authors contributed equally: Youngpyo Nam, Sehwan Kim, Jun-Yeong Lee, Jaekwang Kim.
Correspondence: Sang Ryong Kim

Abstract

Aging-related deterioration of the nigrostriatal dopamine (DA) system, part of the basal ganglia circuitry for motor regulation, leads to reduced motor activity. Currently, there is no evidence linking the long-term preservation of DA neuron activity in the substantia nigra (SN) through anti-aging factors to the prevention of skeletal muscle loss associated with aging. We report that sustained upregulation of sirtuin 3 (SIRT3), a mitochondrial deacetylase that declines with age, using adeno-associated virus serotype 1 (AAV1) encoding Sirt3 in the SN of mice, significantly mitigates aging-related declines in motor activity and skeletal muscle mass. Our study demonstrates that preserving neural activity in the nigrostriatal DA system by maintaining beneficial anti-aging factors in nigral DA neurons can counteract these declines in skeletal muscle mass and locomotor function.

논문정보

형식Research article
게재일2025년 05월 (BRIC 등록일 2025-05-14)
연구진국내 연구진
분야 의약학 > 신경의학

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