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Angew. Chem.-Int. Edit., Apr 29 2025, | https://doi.org/10.1002/anie.202506505
pH-Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy
Qihang Ding # 1, Lina Ding # 2, Chunbai Xiang # 3, Chunbin Li 4, Eunji Kim 1, Changyu Yoon 1, Haoran Wang 4,5, Meijia Gu 6, Pengfei Zhang 3, Lin Wang 2, Ben Zhong Tang 4, Jong Seung Kim 1
1Department of Chemistry, Korea University, Seoul, 02841, South Korea.
2Department of Oral Implantology, School and Hospital of Stomatology, Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Jilin University, Changchun, 130021, China.
3Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
4School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China.
5Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen, 518115, China.
6Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
#Contributed equally.
Corresponding Author : Jong Seung Kim
1Department of Chemistry, Korea University, Seoul, 02841, South Korea.
2Department of Oral Implantology, School and Hospital of Stomatology, Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Jilin University, Changchun, 130021, China.
3Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab for Biomaterials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
4School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China.
5Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen, 518115, China.
6Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
#Contributed equally.
Corresponding Author : Jong Seung Kim
Abstract
Bacterial infections significantly alter the local microenvironment, with acidic byproducts from bacterial metabolism leading to a pronounced pH reduction. Leveraging this characteristic, we synthesized and identified DHTPA, a near-infrared (NIR) fluorescent and pH-responsive aggregation-induced emission (AIE) photosensitizer, for enhanced photodynamic therapy against bacterial infections. DHTPA aggregates exhibit a 2.1-fold increase in ROS generation under weakly acidic conditions (pH 5.5) compared to neutral conditions (pH 7.4), attributed to its pH-dependent electronic structure modulation. Upon NIR light irradiation, DHTPA aggregates precisely respond to the acidic microenvironment, significantly boosting ROS production for efficient bacterial eradication. In vitro studies demonstrated that DHTPA achieved over 99.9% bactericidal efficiency against both gram-negative and gram-positive bacteria. In a murine infected wound model, DHTPA treatment accelerated wound healing by 2.4 times, markedly reduced bacterial burden, and alleviated inflammatory responses, highlighting its therapeutic potential. By integrating NIR activation, pH responsiveness, and AIE properties, DHTPA presents a precise and efficient antibacterial therapeutic strategy, offering an innovative solution for the clinical management of bacterial infections.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-05-13)
- 국내(교신)+국외 연구진
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