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서울대학교 의과대학, 보라매병원

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Clin. Gastroenterol. Hepatol., May 08 2025, S1542-3565(25)00338-6 | https://doi.org/10.1016/j.cgh.2025.01.042 Young adults with metabolic dysfunction-associated steatotic liver disease have an increased risk of early-onset cancer

Joon Ho Moon MD, PhD ^1,2#, Seogsong Jeong MD, PhD ^3#, Heejoon Jang MD ^1,4, Dong Hyeon Lee MD, PhD ^1,4, Sae Kyung Joo MD, PhD ^1,4, Bo Kyung Koo MD, PhD ^1,2, Qiang Xia MD, PhD ⁵, Meng Sha MD, PhD ⁵, Yoosoo Chang MD, PhD ⁶, Won Kim MD, PhD ^1,4
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
²Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
³Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Korea
⁴Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea
⁵Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
⁶Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Corresponding author and person to whom reprint requests should be addressed: Won Kim, MD, PhD

Abstract

Background and aims
We investigated the association between subtypes of steatotic liver disease (SLD) and 23 site-specific cancers in a nationwide cohort of young Korean adults.

Methods
From a nationwide health screening database in Korea, 2,877,245 young adults aged 20–39 years between 2013 and 2014 were included and followed up until December 31, 2022. Individuals were categorized into non-SLD, metabolic dysfunction-associated SLD (MASLD), MASLD with increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD) groups. Hepatic steatosis was defined as a fatty liver index ≥60. The primary outcome was all-cancer, while secondary outcomes included 23 site-specific cancers. Cox proportional hazards regression models were used to estimate hazard ratios (HRs).

Results
During 22,819,681 person-years of follow-up, 46,729 incident cancer cases developed. The MASLD (HR, 1.19; 95% CI, 1.16–1.22; P<0.001) MetALD (HR, 1.12; 95% CI, 1.07–1.18; P<0.001), and ALD (HR, 1.21; 95% CI, 1.12–1.31; P<0.001) groups had a higher risk of all cancers compared to the non-SLD group. Most obesity-related cancers showed increased risk in individuals with either MASLD or MetALD. There was an increasing trend in all-cancer risk with increasing number of cardiometabolic risk factors among MASLD. Alcohol consumption had a modest effect on overall cancer risk, with varying effects on specific cancer types.

Conclusion
Young adults with MASLD, MetALD, or ALD are at increased risk of developing early-onset cancer.

논문정보

형식Research article
게재일2025년 05월 (BRIC 등록일 2025-05-12)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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