이승현 (Harvard Medical School, Massachusetts General Hospital) | 한빛사논문 > 한빛사

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Harvard Medical School, Massachusetts General Hospital

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Biol. Psychiatry, Volume 97, Issue 10, 15 May 2025, Pages 953-960 | https://doi.org/10.1016/j.biopsych.2024.07.007 Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis

SeungHyun Lee ^a, Ziv M. Williams^a,b,c

^aDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
^bHarvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts
^cProgram in Neuroscience, Harvard Medical School, Boston, Massachusetts

Address correspondence to Ziv M. Williams, M.D.

Abstract

Homeostasis is a fundamental concept in biology and ensures the stability of life by maintaining the constancy of physiological processes. Recent years have witnessed a surge in research interest in these physiological processes, with a growing focus on understanding the mechanisms underlying social homeostasis. This shift in focus underscores our increasing understanding of the importance of social interactions and their impact on individual well-being. In this review, we explore the interconnected research across 3 primary categories: understanding the neural mechanisms influencing set points, defining contemporary factors that can disrupt social homeostasis, and identifying the potential contributions of social homeostatic failure in the development of psychiatric diseases. We also delve into the role of the prefrontal cortex and its circuitry in regulating social behavior, decision-making processes, and the manifestation of neuropsychiatric disorders, such as depression and anxiety. Finally, we examine the influence of more recent factors such as growing social media exposure and the COVID-19 pandemic on mental health, highlighting their disruptive effects. We also identify gaps in current literature through the analysis of research trends and propose future research directions to advance our understanding of social homeostasis, with implications for mental health interventions.

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형식Review Paper
게재일2025년 05월 (BRIC 등록일 2025-05-08)
연구진국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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