한빛사
>
한빛사논문
한빛사논문
- 조회76
Asian J. Pharm. Sci., Available online 22 April 2025, 101061 | https://doi.org/10.1016/j.ajps.2025.101061
Amphiphilic Lipid-Peptide Engineered Placenta-Derived Mesenchymal Stem Cells for Liver Fibrosis Treatment
Hee Won Park 1#, Dae Hyun Lee 2#, Sungjun Kim 1, Hyeri Park 2, Ashok Kumar Jangid 1, Chae Eun Lee 1, Jaewon Park 1, Gyu Tae Park 4, Ha Yeon Park 5, HyunJin Kim 5, Jae Ho Kim 4, Gi Jin Kim 2,3, Kyobum Kim 1
1Department of Chemical & Biochemical Engineering, Dongguk University, Seoul, Republic of Korea
2Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-Do, Republic of Korea
3PLABiologics.Co. Ltd., Seongnam-si, Gyeonggi-do, Republic of Korea
4Department of Physiology, College of Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Republic of Korea
5Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea
#These authors are contributed equally to this work.
Corresponding authors : Gi Jin Kim, Kyobum Kim
1Department of Chemical & Biochemical Engineering, Dongguk University, Seoul, Republic of Korea
2Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-Do, Republic of Korea
3PLABiologics.Co. Ltd., Seongnam-si, Gyeonggi-do, Republic of Korea
4Department of Physiology, College of Medicine, Pusan National University, Yangsan 50612, Gyeongsangnam-do, Republic of Korea
5Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea
#These authors are contributed equally to this work.
Corresponding authors : Gi Jin Kim, Kyobum Kim
Abstract
The global rate of death due to liver diseases, particularly liver fibrosis, is increasing. Among various treatment methods, stem cell therapy using placenta-derived mesenchymal stem cells (PDMSCs) offers distinct benefits, including ease of isolation and superior proliferative potential. To enhance the therapeutic efficacy of PDMSCs, WKYMVm peptide was selected for cell engineering. Immobilization of WKYMVm on PDMSC membranes facilitates effective peptide binding to the formyl protein receptor 2 on adjacent PDMSCs and hepatocytes, thereby enhancing cell activation and achieving more efficient peptide utilization compared to bolus peptide treatment. Increased cell activation enhances the secretion of paracrine factors including growth factors and cytokines, which in turn augments liver function and vascular repair in both in vitro and in vivo models. This approach not only enhances the angiogenic and therapeutic capacities of stem cells, but also enables efficient peptide utilization, minimizing potential side effects and costs associated with high peptide dosages. Overall, our study demonstrates significant promise of stem cell therapy for treating liver fibrosis. Thus, stem cell therapy offers considerable prospects for clinical applications.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-05-08)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기
