신순호 (서울대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회80

신순호Soonho Shin

서울대학교 의과대학

Exp. Mol. Med., 07 May 2025 | https://doi.org/10.1038/s12276-025-01456-7 Quantitative dynamics of neural uncertainty in sensory processing and decision-making during discriminative learning

Soonho Shin ^1,2,3, Joonsu Oh ⁴, Sun Kwang Kim⁵, Yong-Seok Lee^1,2,3 and Sang Jeong Kim ^1,2,3,*

¹Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
²Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
³Memory Network Medical Research Center, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
⁴Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada.
⁵Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

^*Corresponding author: correspondence to Sang Jeong Kim

Abstract

Uncertainty is crucial in sensory processing, necessitating further quantitative research on its neural representation in the sensory cortex. Here, to address this need, we used a deep learning approach to quantify uncertainties in neural activity from the forelimb area of the primary somatosensory cortex (fS1) during a vibration frequency discrimination task, introducing a transformer model designed to decode neural data not consistently tracked over time. Our model shows that the neural representation of fS1 encodes uncertainties not only from vibratory stimuli but also from decision-making processes, emphasizing its crucial role across various biological contexts. We confirmed that uncertainty decreases as learning progresses and increases with interruptions in learning. In line with predictions from previous studies, we also observed that uncertainty is high at psychometric thresholds. Furthermore, high uncertainty correlates with incorrect decisions, and we have identified dynamics in uncertainty between previous and current trials. Such findings underscore the evolving role of fS1 in assessing uncertainty for the brain’s downstream areas as learning progresses.

논문정보

형식Research article
게재일2025년 05월 (BRIC 등록일 2025-05-13)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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