신수련 (Harvard Medical School/Brigham and Women’s Hospital) | 한빛사논문 > 한빛사

한빛사논문

조회190

Harvard Medical School/Brigham and Women’s Hospital

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Adv. Drug Deliv. Rev., May 03 2025, S0169-409X(25)00077-8 | https://doi.org/10.1016/j.addr.2025.115592 Enhancing organoid technology with carbon-based nanomaterial biosensors: Advancements, challenges, and future directions

Zahra Rezaei ^a,1, Niyou Wang ^a,1, Yipei Yang ^a,b, Kannan Govindaraj^a,c, Jose Joaquin Velasco ^a,d, Alvaro Dario Martinez Blanco^a,e, Nam Ho Bae^f, HeaYeon Lee ^a,g,h, Su Ryon Shin^a

^aDivision of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
^bDepartment of Orthopedic Surgery, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China
^cDepartment of Developmental Bioengineering, TechMed Centre, University of Twente, Drienerlolaan 5, Enschede 7522NB, the Netherlands
^dMonterrey Institute of Technology, School of Science and Engineering, Eugenio Garza Sada Avenue 2501 South, Monterrey, Nuevo Leon 64849, Mexico
^eMonterrey Institute of Technology, School of Science and Engineering, Epigmenio González 500, Fraccionamiento San Pablo, Santiago de Querétaro, Querétaro 76130, Mexico
^fCenter for Nano-Bio Developement, National NanoFab Center (NNFC), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea
^gMARA Nanotech, INC. 4th floor, Hanmir Hall, Yongdang Campus, Pukyung National University, 365 Sinseon-ro, Nam-gu, Busan 48547, Republic of Korea
^hMARA Nanotech New York, INC. 1 Pennsylvania Plaza, Suite 1423, New York, NY 10119, USA

¹Indicates the authors contribute to the work equally.
Corresponding author : Su Ryon Shin

Abstract

Various carbon-based nanomaterials (CBNs) have been utilized to develop nano- and microscale biosensors that enable real-time and continuous monitoring of biochemical and biophysical changes in living biological systems. The integration of CBN-based biosensors into organoids has recently provided valuable insights into organoid development, disease modeling, and drug responses, enhancing their functionality and expanding their applications in diverse biomedical fields. These biosensors have been particularly transformative in studying neurological disorders, cardiovascular diseases, cancer progression, and liver toxicity, where precise, non-invasive monitoring is crucial for understanding pathophysiological mechanisms and assessing therapeutic efficacy. This review introduces intra- and extracellular biosensors incorporating CBNs such as graphene, carbon nanotubes (CNTs), graphene oxide (GO), reduced graphene oxide (rGO), carbon dots (CDs), and fullerenes. Additionally, it discusses strategies for improving the biocompatibility of CBN-based biosensors and minimizing their potential toxicity to ensure long-term organoid viability. Key challenges such as biosensor integration, data accuracy, and functional compatibility with specific organoid models are also addressed. Furthermore, this review highlights how CBN-based biosensors enhance the precision and relevance of organoid models in biomedical research, particularly in organ-specific applications such as brain-on-a-chip systems for neurodegenerative disease studies, liver-on-a-chip platforms for hepatotoxicity screening, and cardiac organoids for assessing cardiotoxicity in drug development. Finally, it explores how biosensing technologies could revolutionize personalized medicine by enabling high throughput drug screening, patient-specific disease modeling, and integrated sensing platforms for early diagnostics. By capturing current advancements and future directions, this review underscores the transformative potential of carbon-based nanotechnology in organoid research and its broader impact on medical science.

논문정보

형식Review Paper
게재일2025년 05월 (BRIC 등록일 2025-05-07)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오소재

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