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조회73

김영규Young Kyu Kim

국가독성과학연구소

J. Hazard. Mater., Apr 30 2025, 494 S0304-3894(25)01345-7 | https://doi.org/10.1016/j.jhazmat.2025.138430 SARS-CoV-2 infection exacerbates fibrosis and develops new-onset asthma in damaged lung by polyhexamethylene guanidine phosphate

Seulgi Jeon ^a,1, Young Kyu Kim ^b,1, Gyun-baek Seo ^a, Gi Jun Oh ^a, Sun-Taek Leem^b, Jeongah Song ^b, Mi-Jin Yang ^c, Jeongho Hwang ^b, Min-Seok Kim^a

^aCenter for Respiratory Safety Research, Korea Institute of Toxicology, Jeongeup-si, Jeonbuk-do 56212, Republic of Korea
^bCenter for Large Animals Convergence Research, Korea Institute of Toxicology, Jeongeup-si, Jeonbuk-do 56212, Republic of Korea
^cCenter for Translational Toxicologic Research, Korea Institute of Toxicology, Jeongeup-si, Jeonbuk-do 56212, Republic of Korea

¹These authors contributed equally to this work.
Corresponding authors : Jeongho Hwang, Min-Seok Kim

Abstract

Modern society faces a variety of respiratory-related threats from the increased use of chemicals and periodic outbreaks of infectious diseases. This study investigates the connection between chemically-induced lung damage and SARS-CoV-2 infection, addressing a critical research gap. To investigate this connection, we conducted a study using a mouse model to assess SARS-CoV-2 infection symptoms in lungs injured by polyhexamethylene guanidine phosphate (PHMG-p). Our research revealed that PHMG-p-Induced Lung Injury (PILI) mice exhibited severe inflammatory responses and lung damage following infection. Cytokine storm-related factors were significantly elevated in the bronchoalveolar lavage fluids of infected PILI mice, indicating severe infection. RNA-seq analysis showed upregulated genes in infected PILI mice associated with respiratory tract diseases and increased inflammatory and immune responses. Downregulated genes were primarily involved in lipid metabolism processes. We also identified alterations in four _genes linked to asthma development in infected PILI mice, correlating with clinical observations in patients. Our findings suggest that SARS-CoV-2 infection in chemically damaged lungs may exacerbate symptoms and potentially lead to new-onset asthma. This study highlights the increased risk of infection severity in chemically damaged lungs and emphasizes the need for heightened awareness of respiratory health in individuals exposed to chemicals, especially during infectious disease outbreaks.

논문정보

형식Research article
게재일2025년 04월 (BRIC 등록일 2025-05-07)
연구진국내 연구진
분야 생명과학 > 분자생물학

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