한빛사
>
한빛사논문
한빛사논문
- 조회53
김지홍Ji Hong Kim
한양대학교
Nat. Commun., May 02 2025, 16 (1) 4115 | https://doi.org/10.1038/s41467-025-59436-4
Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms
Young-Soo Lim1,14, Ji Hong Kim2,14, Junho Kim3,14, MinhDuc Hoang1, Wonok Kang1,4, Mattew Koh5, Won Hyuk Choi2, Steve Park6,7, Unyong Jeong8, Do Hwan Kim2,9,10 & Sung-Min Park1,11,12,13
1Department of Convergence IT Engineering (CiTE), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2Department of Chemical Engineering, Hanyang University, Seoul, Republic of Korea.
3School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
4Department of Electronic Engineering, Yeungnam University, Gyeongsan, Republic of Korea.
5POSTECH Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
6Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
7KAIST Institute for Health Science and Technology, Daejeon, Republic of Korea.
8Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
9Institute of Nano Science and Technology, Hanyang University, Seoul, Republic of Korea.
10Clean-Energy Research Institute, Hanyang University, Seoul, Republic of Korea.
11Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
12Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
13Institute of Convergence Science, Yonsei University, Seoul, Republic of Korea.
14These authors contributed equally: Young-Soo Lim, Ji Hong Kim, Junho Kim
Corresponding authors
Correspondence to Do Hwan Kim or Sung-Min Park.
1Department of Convergence IT Engineering (CiTE), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2Department of Chemical Engineering, Hanyang University, Seoul, Republic of Korea.
3School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
4Department of Electronic Engineering, Yeungnam University, Gyeongsan, Republic of Korea.
5POSTECH Medical Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
6Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
7KAIST Institute for Health Science and Technology, Daejeon, Republic of Korea.
8Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
9Institute of Nano Science and Technology, Hanyang University, Seoul, Republic of Korea.
10Clean-Energy Research Institute, Hanyang University, Seoul, Republic of Korea.
11Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
12Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
13Institute of Convergence Science, Yonsei University, Seoul, Republic of Korea.
14These authors contributed equally: Young-Soo Lim, Ji Hong Kim, Junho Kim
Corresponding authors
Correspondence to Do Hwan Kim or Sung-Min Park.
Abstract
Optimizing stimulation protocols for peripheral neuromodulation often depends on patient feedback, which can result in inconsistent clinical outcomes. Here we present a closed-loop control system for peripheral nerve stimulation (PNS) that utilizes evoked compound action potential (ECAP) feedback to regulate stimulation parameters, addressing the limitations of traditional methods. Unlike established closed-loop control techniques in the central nervous system, such as local field potential and spike analysis, a comparable approach for the peripheral nervous system remains underdeveloped. ECAPs can be consistently observed across peripheral nerves, providing a reliable measure of nerve activation. We developed a fully implantable device and neural interface for tibial nerve stimulation (TNS) that incorporates the proposed closed-loop system. This TNS system shows promise as a PNS treatment for alleviating overactive bladder symptoms. In a rat model, the system demonstrated longer micturition intervals and greater effectiveness compared to conventional motor response-based control.
논문정보
- Research article
- 2025년 05월 (BRIC 등록일 2025-05-13)
- 국내(교신)+국외 연구진
관련 보도자료
“신경에 귀 기울이다” 배뇨장애 치료, 이제는 ‘맞춤 자극’ 시대
소변을 자주 보거나 배변이 잘되지 않는 증상처럼 다양한 형태로 나타나는 배뇨·배변 장애는 겉으로는 잘 보이지 않지만, 삶의 질에 큰 영향을 미친다. 많은 사람들이 이런 문제를 부끄러워하거나 대수롭지 않게 넘기기도 하지만, 경우에 따라서는 신경계 질환과 관련된 심각한 건강 문제일 수 있어, 조기에 진단받고 꾸준한 치료를 받는 전문적 관리가 반드시 필요하다. 최근 국내 연구진이 이러한 배뇨장애를 보다 정확하고 효과적으로 치료할 수 있는 새로운 신경조절 기술을 개발해 주목받고 있다. 이번 연구는 학계의 주목을 받으며, 세계적인 과학 학술지인 '네이처 커뮤니케이션즈(Nature Communications)'에 지난 2일 게재됐다.
- Bio통신원
- 2025. 05. 08
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
연구자 ID
관련분야 연구자보기
관련분야 논문보기
