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한빛사논문
한빛사논문
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Exp. Mol. Med., May 01 2025, | https://doi.org/10.1038/s12276-025-01451-y
Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles
Deok-Hyeon Cheon 1,2,6, Sheejune Park 2,3,6, Jihyun Park 3, MinSeo Koo 3, Hyun-Hyung Kim 3, Seol Han 3 and Hyung Jin Choi 1,2,3,4,5,*
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
2Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.
3Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
4Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
5Wide River Institute of Immunology, Seoul National University, Gangwon-do, Republic of Korea.
6These authors contributed equally: Deok-Hyeon Cheon, Sheejune Park.
2Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Republic of Korea.
3Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
4Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
5Wide River Institute of Immunology, Seoul National University, Gangwon-do, Republic of Korea.
6These authors contributed equally: Deok-Hyeon Cheon, Sheejune Park.
*Corresponding author: correspondence to Hyung Jin Choi
Abstract
The lateral hypothalamus (LH) is a central hub orchestrating eating behavior through its complex cellular, anatomical and temporal organization. The LH is characterized by high heterogeneity and functional complexity, with many aspects still unexplored. Here we synthesize recent advances in understanding the role of the LH in eating regulation across multiple dimensions. At the cellular level, the LH contains diverse neuronal populations that contribute to distinct roles in behavior. Anatomically, we divided the LH into four regions-anteromedial, anterolateral, posteromedial and posterolateral-each with unique cellular compositions, circuit organizations and projection patterns. By integrating the temporal dynamics of each LH cell type during eating behavior, we identified how various LH cell types are involved in regulating the appetitive and consummatory phases of eating behavior. The LH also plays vital roles in associative learning and different types of eating behavior, including homeostatic, pleasure-induced and stress-induced eating. These insights into LH organization and function provide promising directions for therapeutic interventions in eating disorders and obesity, including drugs, deep brain stimulation and gene therapy.
논문정보
- Review Paper
- 2025년 05월 (BRIC 등록일 2025-05-07)
- 국내 연구진
- 생명과학 > 신경생물학
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