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이준서Jun Seo Lee
성균관대학교
ACS Nano, Apr 28 2025, | https://doi.org/10.1021/acsnano.4c17421
Dual Delivery of Light/Prodrug Nanoparticles Using Tumor-Implantable Micro Light-Emitting Diode on an Optofluidic System for Combinational Glioma Treatment
Jagyeong Goo 1, Jun Seo Lee 2, Junwon Park 3, Seong Ik Jeon 4, Jeongrae Kim 5, Wan Su Yun 5, Nayeon Shim 4, Yujeong Moon 4, Sunejeong Song 4, Jinseong Kim 4, Hanhee Cho 4, Ju Yeon Jeong 2, Ju Seung Lee 2, Sangheon Han 3, Hyeon-Ju Lee 3, Won-Gun Koh 1, Won Seok Chang 3, Tae-Il Kim 2, Kwangmeyung Kim 4,6
1Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2School of Chemical Engineering, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
3Department of Neurosurgery and Brain Research Institute, College of Medicine, Yonsei University, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
4College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
5KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
6Gradutate Program in Innovative Biomaterials Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
J.G., J.S.L., J.P. and S.I.J. contributed equally to this work.
Corresponding Authors : Won Seok Chang, Tae-Il Kim, Kwangmeyung Kim
1Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2School of Chemical Engineering, Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon 16419, Republic of Korea.
3Department of Neurosurgery and Brain Research Institute, College of Medicine, Yonsei University, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
4College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
5KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
6Gradutate Program in Innovative Biomaterials Convergence, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea.
J.G., J.S.L., J.P. and S.I.J. contributed equally to this work.
Corresponding Authors : Won Seok Chang, Tae-Il Kim, Kwangmeyung Kim
Abstract
Glioma is a highly lethal tumor with a poor prognosis, in which the presence of the blood-brain barrier (BBB) and skull significantly limits treatment options. To address this, a tumor-implantable optofluidic system (LED-SC), consisting of a microsized LED (microLED) and a microsyringe chip (SC), is proposed to deliver both light and prodrug nanoparticles (PNPs) directly to brain glioma. The LED-SC combines microLED and SC to enable intratumoral administration of light and PNPs for chemophotodynamic therapy. PNPs, self-assembled nanoparticles of verteporfin (VPF)-doxorubicin (DOX) prodrug, are cleaved by the enzyme cathepsin B, releasing active drugs specifically within tumor cells. In vitro studies show that PNPs are taken up by glioma cells and exhibit enhanced cytotoxicity under light irradiation. The PNPs-loaded LED-SC can be implanted into glioma, wherein PNPs are slowly diffused through the tumor, bypassing the BBB, and it also ensures effective light delivery in glioma beneath the skull, boosting chemo-photodynamic therapy. In glioma mouse models, PNP-loaded LED-SC implantation showed a 3.9-fold improvement in PNP delivery efficiency over intravenous administration, leading to better drug distribution and therapeutic results. The PNPs-loaded LED-SC offers a promising and minimally invasive solution for glioma treatment, overcoming the barriers of the BBB and skull while reducing systemic toxicity.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-30)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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