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김현우Hyun Woo Kim
연세대학교
Nat. Commun., Published: 29 April 2025 | https://doi.org/10.1038/s41467-025-59303-2
Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging
Hyun Woo Kim1,14, Jiwon Kim2,3,14, Jong Youl Kim4,14, Kyubeen Kim1, Ju Young Lee1, Taemin Kim1, Shinil Cho1, Jong Bin An5, Hyun Jae Kim5, Lulu Sun6, Sunghoon Lee6,7, Kenjiro Fukuda6,7, Takao Someya6,7,8, Mingyu Sang9, Young Uk Cho10, Jong Eun Lee2,3,11 & Ki Jun Yu1,12,13
1Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Department of Anatomy, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
3Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
4Department of Anatomy, Catholic Kwandong University College of Medicine, 24, Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601, Republic of Korea.
5Electronic Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
6Thin-Film Device Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351−0198, Japan.
7RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351−0198, Japan.
8Department of Electrical Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113−8656, Japan.
9Department of Electronic Engineering Gachon University, 1342, Seongnam-daero Sujeong-gu, Seongnam-si Gyeonggi-do 13120, Republic of Korea.
10Department of Biomedical & Robotics Engineering, Incheon National University, Yeonsu-gu, Incheon 22012, Republic of Korea.
11Brain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
12Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
13The Biotech Center, Pohang University of Science and Technolopgy (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea.
14These authors contributed equally: Hyun Woo Kim, Jiwon Kim, Jong Youl Kim.
Corresponding authors
Correspondence to Young Uk Cho, Jong Eun Lee or Ki Jun Yu.
1Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Department of Anatomy, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
3Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
4Department of Anatomy, Catholic Kwandong University College of Medicine, 24, Beomil-ro 579beon-gil, Gangneung-si, Gangwon-do 25601, Republic of Korea.
5Electronic Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
6Thin-Film Device Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351−0198, Japan.
7RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351−0198, Japan.
8Department of Electrical Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113−8656, Japan.
9Department of Electronic Engineering Gachon University, 1342, Seongnam-daero Sujeong-gu, Seongnam-si Gyeonggi-do 13120, Republic of Korea.
10Department of Biomedical & Robotics Engineering, Incheon National University, Yeonsu-gu, Incheon 22012, Republic of Korea.
11Brain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
12Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
13The Biotech Center, Pohang University of Science and Technolopgy (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Republic of Korea.
14These authors contributed equally: Hyun Woo Kim, Jiwon Kim, Jong Youl Kim.
Corresponding authors
Correspondence to Young Uk Cho, Jong Eun Lee or Ki Jun Yu.
Abstract
Simultaneous two-photon imaging and electrophysiological recordings offer considerable potential for advancing neurological research and therapies. However, traditional metal-based neural interfaces suffer from photoelectric artifacts, while existing transparent implants rely on opaque interconnect lines to address conductivity limitations. Herein, we developed an optically transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) neural electrode array with transparent electrodes and interconnect lines. Through a formamide, phosphoric acid, and ethylene glycol treatment, the metal-free PEDOT:PSS array achieved an impedance of 45.8 kΩ (at 1 kHz) even with a 20 × 20 µm² size. This advanced performance surpasses previous metal-free transparent neural interfaces and facilitates precise electrophysiological recordings, including extracellular action potentials and low-noise local field potentials. In vivo experiments demonstrated artifact-free two-photon imaging and reliable neural signal acquisition, while biocompatibility tests confirmed negligible cytotoxicity or immune responses. The developed metal-free PEDOT:PSS array provides a robust platform for neural recording and bioimaging, representing an advancement in transparent neural interface technology and integrated optical modalities.
논문정보
- Research article
- 2025년 04월 (BRIC 등록일 2025-04-30)
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