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Clin. Microbiol. Rev., Apr 22 2025, | https://doi.org/10.1128/cmr.00240-24
Recent advances in therapeutic probiotics: insights from human trials
Mu-Yeol Cho1, Je-Hyun Eom1, Eun-Mi Choi1, Seung-Jo Yang2, Dahye Lee3, Young Youn Kim4, Hye-Sung Kim4, Inseong Hwang1
1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation, Goyang-si, South Korea
2DOCSmedi, Co., Ltd., Goyang-si, South Korea
3Department of Orthodontics, Apple Tree Dental Hospital, Goyang-si, South Korea
4Department of Oral and Maxillofacial Surgery, Apple Tree Dental Hospital, Goyang-si, South Korea
Mu-Yeol Cho, Je-Hyun Eom, and Eun-Mi Choi contributed equally to this article.
Address correspondence to Hye-Sung Kim, Inseong Hwang
1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation, Goyang-si, South Korea
2DOCSmedi, Co., Ltd., Goyang-si, South Korea
3Department of Orthodontics, Apple Tree Dental Hospital, Goyang-si, South Korea
4Department of Oral and Maxillofacial Surgery, Apple Tree Dental Hospital, Goyang-si, South Korea
Mu-Yeol Cho, Je-Hyun Eom, and Eun-Mi Choi contributed equally to this article.
Address correspondence to Hye-Sung Kim, Inseong Hwang
Abstract
Recent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome's role in health and disease. However, comprehensive reviews integrating the diverse therapeutic effects of probiotics in human subjects have been limited. By analyzing randomized controlled trials (RCTs) and meta-analyses, this review provides a comprehensive overview of key developments in probiotic interventions targeting gut, liver, skin, vaginal, mental, and oral health. Emerging evidence supports the efficacy of specific probiotic strains and combinations in treating a wide range of disorders, from gastrointestinal (GI) and liver diseases to dermatological conditions, bacterial vaginosis, mental disorders, and oral diseases. We discuss the expanding understanding of microbiome-organ connections underlying probiotic mechanisms of action. While many clinical trials demonstrate significant benefits, we acknowledge areas requiring further large-scale studies to establish definitive efficacy and optimal treatment protocols. The review addresses challenges in standardizing probiotic research methodologies and emphasizes the importance of considering individual variations in microbiome composition and host genetics. Additionally, we explore emerging concepts such as the oral-gut-brain axis and future directions, including high-resolution microbiome profiling, host-microbe interaction studies, organoid models, and artificial intelligence applications in probiotic research. Overall, this review offers a comprehensive update on the current state of therapeutic probiotics across multiple domains of human health, providing insights into future directions and the potential for probiotics to revolutionize preventive and therapeutic medicine.
논문정보
- Review Paper
- 2025년 04월 (BRIC 등록일 2025-04-24)
- 국내 연구진
- 바이오·의료융합 > 바이오·의료융합 기타
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